bloodjourГематология и трансфузиологияRussian journal of hematology and transfusiology0234-57302411-3042ООО Издательский дом «Практика»10.35754/0234-5730-2020-65-4-460-472bloodjour-250Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS OF LITERATUREОпределение минимальной измеримой остаточной болезни у взрослых больных острыми лейкозамиDetection of measurable residual disease in adults with acute leukaemiahttps://orcid.org/0000-0002-8490-6066ГальцеваИ. В.GaltsevaI. V.

Гальцева Ирина Владимировна, кандидат медицинских наук, заведующая научно-клинической лабораторией иммунофенотипирования клеток крови и костного мозга

125167, Москва

Irina V. Galtseva, Cand. Sci. (Med.), Head of the Scientific and Clinical Laboratory for Immunophenotyping of Blood and Bone Marrow Cells

125167, Moscow

irinagaltseva@gmail.comhttps://orcid.org/0000-0001-5932-0285ДавыдоваЮ. О.DavydovaY. O.

Давыдова Юлия Олеговна, врач клинической лабораторной диагностики научно-клинической лаборатории иммунофенотипирования клеток крови и костного мозга

125167, Москва

Yulia O. Davydova, Physician (clinical diagnostics), Scientific and Clinical Laboratory for Immunophenotyping of Blood and Bone Marrow Cells

125167, Moscow

davydova.y@blood.ruhttps://orcid.org/0000-0001-6177-3566ПаровичниковаЕ. Н.ParovichnikovaE. N.

Паровичникова Елена Николаевна, доктор медицинских наук, заведующая отделом химиотерапии гемобластозов, депрессий кроветворения и трансплантации костного мозга

125167, Москва

Elena N. Parovichnikova, Dr. Sci. (Med.), Head of the Department of Chemotherapy for Hemoblastoses, Hematopoietic Depressions and BMT

125167, Moscow

parovichnikova.e@blood.ruФГБУ «Национальный медицинский исследовательский центр гематологии» Министерства здравоохранения Российской ФедерацииРоссияNational Research Center for HematologyRussian Federation202010122020654460472Copyright © Гальцева И.В., Давыдова Ю.О., Паровичникова Е.Н., 20202020Гальцева И.В., Давыдова Ю.О., Паровичникова Е.Н.Galtseva I.V., Davydova Y.O., Parovichnikova E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.htjournal.ru/jour/article/view/250Введение

Введение. Минимальная остаточная болезнь (МОБ) — это небольшое количество опухолевых клеток, которые могут вызвать развитие рецидива после достижения клинико-гематологической ремиссии заболевания.

Цель

Цель: проанализировать прогностическую значимость определения МОБ в разных протоколах терапии острых лейкозов.

Основные сведения

Основные сведения. Обнаружение МОБ имеет высокую прогностическую ценность при острых лимфобластных и миелоидных лейкозах. Количественная оценка остаточных опухолевых клеток используется для стратификации больных на группы риска, отличающиеся по прогнозу развития рецидива. Исходя из данных стратификации больных (в том числе из величины МОБ в определенных контрольных точках), возможно изменение терапевтической тактики, например выполнение трансплантации аллогенных гемопоэтических стволовых клеток. Таким образом, определение МОБ при острых лейкозах стало обязательным направлением научно-клинических исследований.

Introduction

Introduction. Measurable residual disease (MRD) is a residual amount of malignant cells able to invoke relapse after complete haematological remission.

Aim

Aim. Analysis of the MRD prognostic value in various treatment protocols for acute leukaemia.

Main findings

Main findings. MRD is a good prognostic indicator in lymphoblastic and myeloid leukaemia. Quantification of residual tumour cells is used for patient risk stratification according to the relapse prognosis. Stratification data, including MRD estimates at check points, may impact therapy choice, such as transplantation of allogeneic haematopoietic stem cells. Therefore, MRD estimation in acute leukaemia has become mandatory in clinical trial and research.

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The authors declare that there are no conflicts of interest present.