bloodjourГематология и трансфузиологияRussian journal of hematology and transfusiology0234-57302411-3042ООО Издательский дом «Практика»10.18821/0234-5730/2016-61-4-215-217bloodjour-38Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCASE REPORTSКлиническая эффективность комбинации ингибиторов тирозинкиназы 2-го поколения и 5-азацитидина в терапии больного с миелоидным бластным кризом хронического миелолейкозаClinical efficacy of the combination of second generation tyrosine kinase inhibitors and 5-azacitidine in the treatment of chronic myeloid leukemia patient in myeloid blast crisishttps://orcid.org/0000-0002-7762-0107ВласоваЮ. Ю.VlasovaYu. Yu.

Власова Юлия Юрьевна, врач-гематолог поликлинического отделения клиники «НИИ ДОГиТ им. Р.М. Горбачевой»

197022, г. Санкт-Петербург

Vlasova Yulia Yu., MD, doctor-hematologist of the outpatient department clinics 

St.Petersburg, 197022

jj_vlasova@mail.ruhttps://orcid.org/0000-0002-0125-864XМорозоваЕ. В.MorozovaE. V.

197022, г. Санкт-Петербург

St.Petersburg, 197022

https://orcid.org/0000-0001-6559-6931СмирноваА. Г.SmirnovaA. G.

197022, г. Санкт-Петербург

St.Petersburg, 197022

https://orcid.org/0000-0002-1302-3311ГиндинаТ. Л.GindinaT. L.

197022, г. Санкт-Петербург

St.Petersburg, 197022

https://orcid.org/0000-0002-1235-4530АфанасьевБ. В.AfanasievB. V.

197022, г. Санкт-Петербург

St.Petersburg, 197022

ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииРоссияI.P. Pavlov First St. Petersburg State Medical UniversityRussian Federation201628022019614215217Copyright © Власова Ю.Ю., Морозова Е.В., Смирнова А.Г., Гиндина Т.Л., Афанасьев Б.В., 20192019Власова Ю.Ю., Морозова Е.В., Смирнова А.Г., Гиндина Т.Л., Афанасьев Б.В.Vlasova Y.Y., Morozova E.V., Smirnova A.G., Gindina T.L., Afanasiev B.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.htjournal.ru/jour/article/view/38

Несмотря на достигнутые успехи в эру ингибиторов тирозинкиназ, прогноз больных хроническим миелолейкозом с миелоидным бластным кризом остается неблагоприятен. Миелоидный бластный криз характеризуется рефрактерностью к цитотоксическим агентам и высоким риском рецидива. В статье представлены данные литературы об использовании гипометилирующих агентов в терапии миелоидного бластного криза хронического миелолейкоза, а также описание клинического случая успешной терапии больного хроническим миелолейкозом с миелоидным бластным кризом комбинацией ингибиторов тирозинкиназы 2-го поколения и 5-азацитидина.

Even in the tyrosine kinase inhibitors era, the prognosis of patients with chronic myeloid leukemia in myeloid blast crisis remains to be unfavorable. Myeloid blast crisis is characterized to be refractory to cytotoxic agents and high risk of recurrence. We described the patient with chronic myeloid leukemia in myeloid blast crisis who was successfully treated by the combination of the second generation tyrosine kinase inhibitor and 5-azacytidine.

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The authors declare that there are no conflicts of interest present.