bloodjourГематология и трансфузиологияRussian journal of hematology and transfusiology0234-57302411-3042ООО Издательский дом «Практика»10.18821/0234-5730-2016-61-2-100-104bloodjour-48Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS OF LITERATUREПолиморфизм генов MICA и MICB в комплексе МНСMajor histocompatibility complex class I chain-related gene A (MICA) and B (MICB) polymorphismhttps://orcid.org/0000-0002-5759-0553ЗайцеваГ. А.ZaitsevaG. A.

Зайцева Галина Алексеевна, доктор мед. наук, профессор, руководитель научного направления

610027, г. Киров

Zaitseva Galina A., MD, PhD, professor, head of the scientifc direction

Kirov, 610027

immunlab@yandex.ruhttps://orcid.org/0000-0003-1846-8237КиселеваА. Н.KiselevaA. N.

610027, г. Киров

https://orcid.org/0000-0003-3431-5273ПарамоновИ. В.ParamonovI. V.

610027, г. Киров

ФГБУН «Кировский научно-исследовательский институт гематологии и переливания крови» ФМБА РоссииРоссияKirov Research Institute of Hematology and Blood TransfusionRussian Federation201601032019612100104Copyright © Зайцева Г.А., Киселева А.Н., Парамонов И.В., 20192019Зайцева Г.А., Киселева А.Н., Парамонов И.В.Zaitseva G.A., Kiseleva A.N., Paramonov I.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.htjournal.ru/jour/article/view/48

Представлены данные литературы, отражающие структуру и функцию открытых в конце XX века генов локуса MIC, характеризующихся высоким полиморфизмом. Показано, что они играют важную роль в процессах межклеточного взаимодействия, участвуют в реализации реакций врожденного и адаптивного иммунитета в качестве лигандов для рецепторов NKG2D, экспрессированных на различных субпопуляциях Т-лимфоцитов. Изложены известные на сегодняшний день сведения об ассоциативной связи генов локуса MIC с заболеваниями, их влияние на исход трансплантаций. Один из разделов статьи посвящен анализу популяционных особенностей распределения аллелей MICA и MICB. Использованы 62 источника литературы, из них 3 отечественных, 47 зарубежных, представленных в следующих информационных системах: PubMed, Google Scholar, Scopus, Springer, The Cochrane Library, Wiley Online Library, РИНЦ.

There are presented data of the literature about the structure and function of the opened at the end of XX century the genes of the MIC locus, characterized by high polymorphism. They play an important role in cell-cell interactions involved in the implementation of responses of the innate and adaptive immunity as ligands for the NKG2D receptors expressed on different subpopulations of T-lymphocytes. There is relationship between MIC locus genes with diseases and their impact on the outcome of transplants. Population characteristics and distribution of MICA and MICB alleles are described.

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The authors declare that there are no conflicts of interest present.