bloodjourГематология и трансфузиологияRussian journal of hematology and transfusiology0234-57302411-3042ООО Издательский дом «Практика»10.35754/0234-5730-2024-69-2-200-216bloodjour-548Research ArticleОБЗОРЫREVIEWSОсобенности Т-клеточного иммунного ответа у пациентов с онкогематологическими заболеваниями после перенесенной инфекции SARS-CoV-2 и вакцинацииFeatures of the T-cell immune response in patients with hematological diseases after SARS-CoV-2 infection and vaccinationhttps://orcid.org/0000-0002-9568-2109ЗорниковаК. В.ZornikovaK. V.

Зорникова Ксения Викторовна, кандидат биологических наук, научный сотрудник лаборатории трансплантационной иммунологии

125167, г. Москва

Ksenia V. Zornikova, Cand Sci (Biol.), Researcher, Laboratory of Transplantation Immunology

125167, Moscow

kvzornikova@gmail.comhttps://orcid.org/0000-0002-4725-6391ИвановаН. О.IvanovaN. O.

Иванова Наталия Олеговна, молекулярный биолог лаборатории трансплантационной иммунологии

125167, г. Москва

Natalia O. Ivanova, Molecular biologist, Laboratory of Transplantation Immunology

125167, Moscow

ivanova.n@blood.ruhttps://orcid.org/0000-0002-9969-8482АлешинаО. А.AleshinaO. A.

Алешина Ольга Александровна, кандидат медицинских наук, заведующая отделом клеточной и иммунной терапии, гематолог отделения гематологии и химиотерапии острых лейкозов и лимфом

125167, г. Москва

Olga A. Aleshina, Cand Sci (Med), Head of the Laboratory of cell and immune therapy, Hematologist, Department of Hematology and Chemotherapy of Acute Leukemia and Lymphomas

125167, Moscow

dr.gavrilina@mail.ruhttps://orcid.org/0000-0002-0975-0938ШитиковС. А.SheetikovS. A.

Шитиков Савелий Андреевич, научный сотрудник лаборатории трансплантационной иммунологии

125167, г. Москва

Sheetikov A. Saveliy, Researcher, Laboratory of Transplantation Immunology

125167, Moscow

sheetikov.s@blood.ruhttps://orcid.org/0009-0005-9983-3225ДавыдоваВ. Д.DavydovaV. D.

Давыдова Васса Дмитриевна,  лаборант лаборатории трансплантационной иммунологии

125167, г. Москва

Vassa D. Davydova,  laboratory assistant, Laboratory of Transplantation Immunology

125167, Moscow

davydova.v@blood.ruhttps://orcid.org/0000-0002-8664-6341БоголюбоваА. В.BogolyubovaA. V.

Боголюбова  Аполлинария Васильевна, кандидат биологических наук, заведующая лабораторией трансплантационной иммунологии

125167, г. Москва

Apollinariya V. Bogolyubova, Cand. Sci. (Biol.), Head of the Laboratory of Transplantation Immunology

125167, Moscow

apollinariya.bogolyubova@gmail.comФГБУ «Национальный медицинский исследовательский центр гематологии» Министерства здравоохранения Российской ФедерацииРоссияNational Medical Research Center for HematologyRussian Federation202418082024692200216Copyright © Зорникова К.В., Иванова Н.О., Алешина О.А., Шитиков С.А., Давыдова В.Д., Боголюбова А.В., 20242024Зорникова К.В., Иванова Н.О., Алешина О.А., Шитиков С.А., Давыдова В.Д., Боголюбова А.В.Zornikova K.V., Ivanova N.O., Aleshina O.A., Sheetikov S.A., Davydova V.D., Bogolyubova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.htjournal.ru/jour/article/view/548Введение

Введение.  Онкогематологические больные являются одной из наиболее уязвимых групп для инфекционных заболеваний. Нарушения работы иммунной системы, вызванные заболеванием и/или его терапией, негативно влияют на длительность и тяжесть инфекции, приводят к повышенному риску смерти и снижают эффективность вакцинации. Однако компенсаторные механизмы, позволяющие иммунокомпрометированным больным бороться с вирусной инфекцией, не до конца изучены.

Цель

Цель: систематизировать знания о формировании иммунного ответа у онкогематологических больных с нарушениями гуморального или клеточного звена.

Основные сведения

Основные сведения. Проведен анализ особенностей Т-клеточного иммунного ответа у  онкогематологических больных. Обсуждено, как разнообразие репертуара Т-клеточных рецепторов может влиять на эффективную элиминацию и защиту от заражения вирусом SARS-CoV-2.

Introduction

Introduction. Patients with hematological malignancies are one of the most vulnerable groups to infectious diseases. Immune system dysfunction caused by the disease and/or its therapy negatively affects infection disease duration and severity, leads to an increased risk of death, and reduces the efficacy of vaccination. However, the precise compensatory mechanisms that allow patients with deficient cellular or humoral responses to fight viral infections have not been sufficiently studied.

Aim

Aim: To systematize the knowledge of immune response formation in patients with hematological malignancies with humoral or cellular dysfunction.

Main findings

Main findings.  In this review the features of the T-cell immune response in patients with hematological malignancies is explored, followed by a discussion on how the diversity of the T-cell receptor repertoire may be important in effective virus elimination and protection against SARS-CoV-2 virus infection.

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The authors declare that there are no conflicts of interest present.