bloodjourГематология и трансфузиологияRussian journal of hematology and transfusiology0234-57302411-3042ООО Издательский дом «Практика»10.35754/0234-5730-2025-70-3-383-395bloodjour-664Research ArticleОБЗОРЫREVIEWSСвободно циркулирующая ДНК при агрессивных зрелоклеточных В-клеточных лимфомах и лимфоме ХоджкинаCell free DNA in patient with aggressive mature cell B-cell lymphomas and Hodgkin’s lymphoma (literature review)https://orcid.org/0000-0001-6220-8868СмирноваС. Ю.SmirnovaS. Yu.

Смирнова Светлана Юрьевна, кандидат медицинских наук, гематолог клинико-диагностического отделения гематологии и химиотерапии с дневным стационаром; научный сотрудник лаборатории молекулярной гематологии

125167, г. Москва

Svetlana Yu. Smirnova, Cand. Sci. (Med.), hematologist of the clinical diagnostic department of hematology and chemotherapy with a day hospital; Researcher, Laboratory of Molecular Hematology

125167, Moscow

smirnova-s-ju@yandex.ruhttps://orcid.org/0000-0003-3914-8611НикулинаЕ. Е.NikulinaE. E.

Никулина Елена Евгеньевна, научный сотрудник лаборатории молекулярной гематологии

125167, г. Москва

Elena E. Nikulina, Researcher, Laboratory of Molecular Hematology

125167, Moscow

lenysh2007@rambler.ruhttps://orcid.org/0000-0001-9463-9187СудариковА. Б.SudarikovA. B.

Судариков Андрей Борисович, доктор биологических наук, заведующий лабораторией молекулярной гематологии

125167, г. Москва

Andrey B. Sudarikov, Dr. Sci. (Biol.), Head of the Laboratory of Molecular Genetics

125167, Moscow

dusha@blood.ruФГБУ «Национальный медицинский исследовательский центр гематологии» Министерства здравоохранения Российской ФедерацииРоссияNational Medical Research Center for HematologyRussian Federation202505102025703383395Copyright © Смирнова С.Ю., Никулина Е.Е., Судариков А.Б., 20252025Смирнова С.Ю., Никулина Е.Е., Судариков А.Б.Smirnova S.Y., Nikulina E.E., Sudarikov A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.htjournal.ru/jour/article/view/664Введение

Введение. Изучение свободно циркулирующей ДНК (сцДНК) в плазме крови при гематологических заболеваниях вызывает все больший интерес. Накоплен значительный объем данных относительно диагностической и прогностической значимости выявления сцДНК и опухолевой сцДНК (соДНК) у онкогематологических больных.

Цель обзора литературы

Цель обзора литературы: анализ данных о значении выявления сцДНК при агрессивных В-клеточных лимфомах и лимфоме Ходжкина.

Основные сведения

Основные сведения. Представлены литературные данные по изучению сцДНК, возможностей и ограничений различных методов исследования сцДНК у больных агрессивными В-клеточными лимфомами и лимфомой Ходжкина.

Introduction

Introduction. Cell free DNA (cfDNA), being an easily accessible and promising clinical material, as previously shown in obstetrics and general oncology, is of particular interest in hematology. In recent years, the study of plasma cfDNA in hematological diseases has been gaining increasing interest among researchers and physicians. To date, a signifi cant amount of data cfDNA and tumor cfDNA (cftDNA) in patients with diseases of the blood system has been accumulated in the world literature.

Aim

Aim: to study the literature data on the cfDNA in aggressive B-cell lymphomas and Hodgkin’s lymphoma (HL).

Main fi ndings

Main fi ndings. The review presents the literature data on the study of cfDNA, the possibilities and limitations of using various methods of studying cfDNA in patients with aggressive B-cell lymphomas and HL.

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The authors declare that there are no conflicts of interest present.