bloodjourГематология и трансфузиологияRussian journal of hematology and transfusiology0234-57302411-3042ООО Издательский дом «Практика»10.18821/0234-5730-2017-62-4-180-187bloodjour-669Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESМобилизация гемопоэтических стволовых клеток препаратами циклофосфамид и цитарабин в сочетании с колониестимулирующим фактором у больных множественной миеломой, кандидатов для проведения трансплантации аутологичных гемопоэтических стволовых клетокMobilization of hematopoietic stem cells with cyclophosphamide or cytarabine in combination with granulocyte colony-stimulating factor in patients with multiple myeloma, who are candidates for autologous stem cell transplantationhttps://orcid.org/0000-0003-2700-5605БабенецкаяД. В.BabenetskayaD. V.

Бабенецкая Диана Валерьевна, врач-гематолог

197341, Санкт-Петербург

Babenetskaya D.V., hematologist

St. Petersburg, 197341

dia86@mail.ruhttps://orcid.org/0000-0001-5189-6722МоторинД. В.MotorinD. V.

197341, Санкт-Петербург

St. Petersburg, 197341

https://orcid.org/0000-0003-3524-311XПетровА. В.PetrovA. V.

197341, Санкт-Петербург

St. Petersburg, 197341

https://orcid.org/0000-0003-4821-4158АлексееваЮ. А.AlekseevaYu. A.

197341, Санкт-Петербург

St. Petersburg, 197341

https://orcid.org/0000-0001-7682-440XЗарицкийА. Ю.ZaritskeyA. Yu.

197341, Санкт-Петербург

St. Petersburg, 197341

ФГБУ «Северо-Западный федеральный медицинский исследовательский центр им. В.А. Алмазова» Минздрава РоссииРоссияFederal Almazov North-West Medical Research CentreRussian Federation201717102025624180187Copyright © Бабенецкая Д.В., Моторин Д.В., Петров А.В., Алексеева Ю.А., Зарицкий А.Ю., 20252025Бабенецкая Д.В., Моторин Д.В., Петров А.В., Алексеева Ю.А., Зарицкий А.Ю.Babenetskaya D.V., Motorin D.V., Petrov A.V., Alekseeva Y.A., Zaritskey A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.htjournal.ru/jour/article/view/669

Проведено сравнение разных режимов мобилизации гемопоэтических стволовых клеток: стимуляция гранулопоэза с помощью только колониестимулирующего фактора и мобилизационные режимы с применением циклофосфамида и цитарабина, произведена оценка их эффективности и токсичности.  У 91% больных получен трансплантат достаточной клеточности. У больных в полной ремиссии количество CD34+-клеток, собранных за 1-й сеанс лейкоцитафереза и за всю мобилизацию, было больше, чем у больных без ремиссии заболевания. Выявлена значимая корреляция между количеством СD34+-клеток в крови в день проведения лейкоцитафереза и клеточностью полученного продукта. Общее количество полученных CD34+-клеток было выше при использовании мобилизации с применением химиотерапии (ХТ). При сравнении двух групп мобилизации с применением ХТ количество CD34+-клеток в крови в день лейкоцитафереза было незначимо выше в группе с применением цитарабина (р = 0,173). По другим анализируемым параметрам эффективности не было показано значимых различий между двумя группами. Показана меньшая токсичность в группе цитарабина.

In our research the comparison of different regimes of mobilization of HSC were carried out. First regime: conduct stimulation of granulopoiesis using granulocyte colony-stimulating factor (GCSF). Other regimes: of mobilization with chemotherapy (cyclophosphamide or cytarabine). The efficiency and the toxicity were  assessed. The grafts with satisfactory cellularity were obtained in 91% patients. The number of CD34+ cell/ml were obtained in the first apheresis and from whole mobilization in patients with complete remission (CR) were more than the number of in patients with < CR. CD34+ cell number in the blood correlate well with total number of CD34+ yielded from apheresis in same day. The number of CD34+ cells/microliter yielded from mobilization was more in group with сhemomobilization than in group with GCSF only. In comparison two groups of сhemomobilization: the number of CD34+ in peripheral blood in day apheresis was more in group with  AraC-GCSF; р = 0.173. There was revealed lesser toxicity in group with AraC-GCSF.

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The authors declare that there are no conflicts of interest present.