Role of granzyme B in T regulatory cells in patients after allogeneic stem cell transplantation
M. Yu. Drokov,
E. N. Parovichnikova,
L. A. Kuzmina,
I. V. Galtseva,
V. A. Vasilieva,
E. D. Mikhaltsova,
O. M. Koroleva,
D. S. Dubnyak,
V. G. Savchenko https://doi.org/10.18821/0234-5730-2016-61-1-32-37
Abstract
The role of regulatory T-cells (T-reg) in the development of autoimmune complications after allogeneic bone marrow transplantation (allo-BMT) is to control the augmented response of donor effector cells. The main mechanisms of immune regulation are the secretion of cytokines, induction of metabolic disturbances in target cells, modification of dendritic cells, direct cytolysis of T effector cells. One of the regulatory mechanisms that use T-reg is a direct cytolysis, the major mediator is granzyme B. Granzyme B plays a key role in maintaining the immune homeostasis. Preliminary data from a qualitative and quantitative assessment of granzyme B-positive T-reg in 30 patients after allo-BMT endorse this role.
Keywords
Supporting agencies: The study was supported by research topic “Development of new technologies of prevention and treatment of alloimmune complications after allogeneic hematopoietic stem cells transplantation in patients with leukemia” in Hematological Research Center (Moscow).
About the Authors
M. Yu. Drokov
National Research Center for Hematology
Russian Federation
Russian Federation
Drokov Mikhail Yu., MD, PhD, Research Offcer of Clinical Research Department of High-Dose Chemotherapy Hemoblastosis, Depression of Hematopoiesis and Bone Marrow Transplantation
Scopus Author ID 48661939800
Moscow, 125167
E. N. Parovichnikova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
L. A. Kuzmina
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
I. V. Galtseva
National Research Center for Hematology
Russian Federation
Scopus Author ID: 6506926619Moscow, 125167
Russian Federation
Scopus Author ID: 6506926619Moscow, 125167
V. A. Vasilieva
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
E. D. Mikhaltsova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
O. M. Koroleva
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
D. S. Dubnyak
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
V. G. Savchenko
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
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Review
For citations:
Drokov M.Yu., Parovichnikova E.N., Kuzmina L.A., Galtseva I.V., Vasilieva V.A., Mikhaltsova E.D., Koroleva O.M., Dubnyak D.S., Savchenko V.G. Role of granzyme B in T regulatory cells in patients after allogeneic stem cell transplantation. Russian journal of hematology and transfusiology. 2016;61(1):32-37. (In Russ.) https://doi.org/10.18821/0234-5730-2016-61-1-32-37
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