Preview

Russian journal of hematology and transfusiology

Advanced search

Vitamin K dependent hemorrhagic conditions in infants after the newborn period

https://doi.org/10.18821/0234-5730-2016-61-1-54-56

Abstract

Vitamin K plays a special role in the blood clotting system, as this vitamin is essential for the synthesis of coagulation factors (II, VII, IX, X, proteins C and S) in the liver. Vitamin K in newborns matures to a certain time and the level of vitamin K dependent factors to the age of 6 months should achieve the standards of an adult human. The most frequent complications of abnormalities in the synthesis of vitamin K-dependent factors are hemorrhagic syndromes. There has recently been an increase in cases of hemorrhagic conditions not only in newborns but also in children of early age due to the lack of prevention of vitamin K deficiency at birth. The article analyzes the observation of hemorrhagic conditions developed after the neonatal period in patients with various chronic diseases.

About the Authors

O. B. Gordeeva
Scientifc Center of Children’s Health
Russian Federation

Gordeeva Olga B., MD, PhD, Senior Research Offcer of Laboratory of Experimental Immunology and Virology the Laboratory of Experimental Immunology and Virology

Moscow, 119991

 



R. F. Tepaev
Scientifc Center of Children’s Health; I.M. Sechenov First Moscow State Medical University
Russian Federation

Moscow, 119991



B. B. Botvineva
Scientifc Center of Children’s Health
Russian Federation
Moscow, 119991


O. K. Botvinev
I.M. Sechenov First Moscow State Medical University
Russian Federation
Moscow, 119991


O. I. Simonova
Scientifc Center of Children’s Health
Russian Federation
Moscow, 119991


Yu. V. Gorinova
Scientifc Center of Children’s Health
Russian Federation
Moscow, 119991


References

1. Momot A.P. Pathology of hemostasis. St.Peterburg: Format; 2006. (in Russian)

2. International statistical classifcation of diseases and problems related to health. ICD 10. Moscow: Meditsina; 2003. vol.1. (in Russian)

3. Shabalov N.P. Neonatology. Moscow: Medpress-inform; 2009. (in Russian)

4. Barkagan Z.S., Momot A.P. Diagnostics and controlled therapy of disorders of hemostasis. Moscow: Nyudiamed; 2001. (in Russian)

5. Weston B.W., Monahan P.E. Familial defciently of vitamin K-dependent clotting factors. Haemophilia. 2008; 14(6): 1209–13. doi: 10.1111/j.1365-2516.20

6. Dolgov V.V., Svirin P.V. Laboratory diagnosis of disorders of hemostasis. Moscow: Triada; 2005. (in Russian)

7. Botviniyev O.K. Systematic analysis of the links between phenotypic characteristics and health status of children. Dis. Moscow; 1985. (in Russian)

8. Zaplatnikov A.L., Dmitriev Y.A., Shishkin S.V., Kataeva L.A., Brazhnikova O.V., Gavela N. Late hemorrhagic disease of the newborn. Medical Journal of the Russian Federation (Rossiyskii meditsinskii zhurnal). 2014; 21: 1547–50. (in Rissian)

9. Ozdemir M.A. Late-type vitamin K defciency bleeding: experience from 120 patients. Childs Nerv. Syst. 2012; 28(2): 247–51.


Review

For citations:


Gordeeva O.B., Tepaev R.F., Botvineva B.B., Botvinev O.K., Simonova O.I., Gorinova Yu.V. Vitamin K dependent hemorrhagic conditions in infants after the newborn period. Russian journal of hematology and transfusiology. 2016;61(1):54-56. (In Russ.) https://doi.org/10.18821/0234-5730-2016-61-1-54-56

Views: 5783


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0234-5730 (Print)
ISSN 2411-3042 (Online)