Treosulfan-based conditioning regimen for allogeneic stem cell transplantation in adult patients with hematological malignancies is non toxic, but not myeloablative
N. N. Popova,
L. A. Kuzmina,
E. N. Parovichnikova,
M. Yu. Drokov,
V. A. Vasilyeva,
E. D. Mikhaltsova,
O. M. Koroleva,
D. S. Dubnyak,
V. G. Savchenko https://doi.org/10.18821/0234-5730/2016-61-4-172-177
Abstract
For many decades the main myeloablative conditioning regimen prior to allogeneic hematopoietic stem cell transplant (allo-HCT) consists of busulfan (16 mg/kg) and cyclophosphamide (120 mg/kg). The rate of transplanted-related mortality as a result of toxicity is still high. However alternative regimens are now available. These regimens allow to reduce toxicity and to get favorable outcomes. Aware of the serious toxic complications when using high doses of busulfan initiated the search for alternative programs. We studied conditioning regimen of the therapy with treosulfan 36 g/m2+ cyclophosphamide 120 mg/m2 as myeloablative, but low toxic for allo-HCT in 18 patients with hematological malignancies from the high-risk group (allo-HCT has been performed not in first remission, patients with unfavorable cytogenetic abnormalities). The median of the age was 27 years (from 19 to 40 years). During the early posttransplant period no severe toxic complications were registered in the study group. Not bad results were got during 2 years after allo-HCT. The overall survival rate in the group of patients with acute myeloid leukemia accounted for 77.8% and in the group of patients with acute lymphoblastic leukemia – 66.7%. On the day +30 full donor chimerism was detected only in 12 patients (66%). However on day +90 in 8 cases (44.4%) the graft rejection was recorded.
About the Authors
N. N. Popova
National Research Center for Hematology
Russian Federation
Russian Federation
Popova Natalia N., MD, doctor-haematologist of the Research Clinical Department of the high-dose chemotherapy, depression of hematopoiesis and bone marrow transplant
Moscow, 125167
L. A. Kuzmina
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
E. N. Parovichnikova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
M. Yu. Drokov
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
V. A. Vasilyeva
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
E. D. Mikhaltsova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
O. M. Koroleva
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
D. S. Dubnyak
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
V. G. Savchenko
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
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For citations:
Popova N.N., Kuzmina L.A., Parovichnikova E.N., Drokov M.Yu., Vasilyeva V.A., Mikhaltsova E.D., Koroleva O.M., Dubnyak D.S., Savchenko V.G. Treosulfan-based conditioning regimen for allogeneic stem cell transplantation in adult patients with hematological malignancies is non toxic, but not myeloablative. Russian journal of hematology and transfusiology. 2016;61(4):172-177. (In Russ.) https://doi.org/10.18821/0234-5730/2016-61-4-172-177
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