Значение минимальной остаточной болезни при хроническом лимфолейкозе в эру таргетных лекарственных препаратов
https://doi.org/10.18821/0234-5730/2016-61-4-190-196
Аннотация
Полная ремиссия (ПР) и длительная беспрогрессивная выживаемость (БПВ) могут быть достигнуты уже после первой линии химиоиммунотерапии у большинства больных хроническим лимфолейкозом (ХЛЛ). Тем не менее в костном мозге значительного числа больных с ПР заболевания иммунологическими и генетическими методами выявляют некоторое количество опухолевых клеток (более 1 на 10 000 нормальных клеток), которые определяют суть минимальной остаточной болезни (МОБ). МОБ-негативный статус больного ассоциируется с длительной БПВ и общей выживаемостью и является единственным благоприятным прогностическим фактором, определяемым после терапии. Появление таргетных препаратов терапии ХЛЛ (ибрутиниб, иделалисиб, венетоклакс), имеющих высокую эффективность и низкий профиль токсичности, позволяет надеяться на увеличение числа МОБ-негативных ремиссий, а изменение тактики лечения – на решение проблемы контроля за остаточным опухолевым клоном.
Ключевые слова
Об авторах
А. Ю. Кувшинов
ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии» ФМБА России
Россия
Россия
Кувшинов Алексей Юрьевич, младший научный сотрудник научной лаборатории
191024, г. Санкт-Петербург
С. В. Волошин
ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии» ФМБА России
Россия
191024, г. Санкт-Петербург
Россия
191024, г. Санкт-Петербург
И. С. Мартынкевич
ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии» ФМБА России
Россия
191024, г. Санкт-Петербург
Россия
191024, г. Санкт-Петербург
Е. В. Клеина
ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии» ФМБА России
Россия
191024, г. Санкт-Петербург
Россия
191024, г. Санкт-Петербург
А. В. Чечеткин
ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии» ФМБА России
Россия
191024, г. Санкт-Петербург
Россия
191024, г. Санкт-Петербург
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Рецензия
При поддержке: Работа выполнена в рамках НИР «Остаточная болезнь-15».
Для цитирования:
Кувшинов А.Ю., Волошин С.В., Мартынкевич И.С., Клеина Е.В., Чечеткин А.В. Значение минимальной остаточной болезни при хроническом лимфолейкозе в эру таргетных лекарственных препаратов. Гематология и трансфузиология. 2016;61(4):190-196. https://doi.org/10.18821/0234-5730/2016-61-4-190-196
For citation:
Kuvshinov A.Yu., Voloshin S.V., Martynkevich I.S., Kleina E.V., Chechetkin A.V. The meaning of the minimal residual disease in chronic lymphocytic leukemia in the era of targeted drugs. Russian journal of hematology and transfusiology. 2016;61(4):190-196. (In Russ.) https://doi.org/10.18821/0234-5730/2016-61-4-190-196
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