Clinical efficacy of the combination of second generation tyrosine kinase inhibitors and 5-azacitidine in the treatment of chronic myeloid leukemia patient in myeloid blast crisis
https://doi.org/10.18821/0234-5730/2016-61-4-215-217
Abstract
Even in the tyrosine kinase inhibitors era, the prognosis of patients with chronic myeloid leukemia in myeloid blast crisis remains to be unfavorable. Myeloid blast crisis is characterized to be refractory to cytotoxic agents and high risk of recurrence. We described the patient with chronic myeloid leukemia in myeloid blast crisis who was successfully treated by the combination of the second generation tyrosine kinase inhibitor and 5-azacytidine.
About the Authors
Yu. Yu. Vlasova
I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Vlasova Yulia Yu., MD, doctor-hematologist of the outpatient department clinics
St.Petersburg, 197022
E. V. Morozova
I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
St.Petersburg, 197022
Russian Federation
St.Petersburg, 197022
A. G. Smirnova
I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
St.Petersburg, 197022
Russian Federation
St.Petersburg, 197022
T. L. Gindina
I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
St.Petersburg, 197022
Russian Federation
St.Petersburg, 197022
B. V. Afanasiev
I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
St.Petersburg, 197022
Russian Federation
St.Petersburg, 197022
References
1. Kantarjian H.M., Shan J., Smith T., Talpaz M., Kozuch P., Rios M.B., et al. Response to therapy is independently associated with survival prolongation in chronic myelogenous leukemia in the blastic phase. Cancer. 2001; 92(10): 2501–7.
2. Sacchi S., Kantarjian H.M., O’Brien S., Cortes J., Rios M.B., Giles F.J., et al. Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the results of first salvage therapy with three different treatment approaches for 162 patients. Cancer.1999; 86(12): 2632–41.
3. Gratwohl A., Hermans J., Niederwieser D., Frassoni F., Arcese W., Gahrton G., et al. Bone marrow transplantation for chronic myeloid leukemia: long-term results Chronic Leukemia Working Party of the European Group for Bone Marrow Transplantation. Bone Marrow Transplant. 1993; 12(5): 509–16.
4. Cortes J., Kim D.W., Raffoux E., Martinelli G., Ritchie E., Roy L., et al. Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase. Leukemia. 2008; 22(12): 2176–83. doi: 10.1038/leu.2008.221.
5. Kantarjian H.M., Cortes J., O’Brien S., Giles F.J., Albitar M., Rios M.B., et al. Imatinib mesylate (STI571) therapy for Philadelphia chromosomepositive chronic myelogenous leukemia in blast phase. Blood. 2002; 99(10): 3547–53.
6. Palandri F., Castagnetti F., Testoni N., Luatti S., Marzocchi G., Bassi S., et al.; GIMEMA Working Party on Chronic Myeloid Leukemia. Chronic myeloid leukemia in blast crisis treated with imatinib 600 mg: outcome of the patients alive after a 6-year follow-up. Haematologica. 2008; 93(12): 1792–6. doi: 10.3324/haematol.13068.
7. Sawyers C.L., Hochhaus A., Feldman E., Goldman J.M., Miller C.B., Ottmann O.G., et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood. 2002; 99(10): 3530–9.
8. Sureda A., Carrasco M., Miguel M., Martinez J.A., Conde E., Sanz M.A., et al. Imatinib mesylate as treatment for blastic transformation of Philadelphia chromosome positive chronic myelogenous leukemia. Haematologica. 2003; 88(11): 1213–20.
9. Saglio G., Hochhaus A., Goh Y.T., MassziT., Pasquini R., Maloisel F., et al. Dasatinib in imatinibresistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study: efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice daily. Cancer. 2010; 116(16): 3852–61. doi: 10.1002/cncr.25123.
10. Deau B., Nicolini F., Guilhot J., Huguet F., Guerci A., Legros L., et al. The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01study). Leuk. Res. 2011; 35(6): 777–82. doi: 10.1016/j.leukres.2010.11.004.
11. Fruehauf S., Topaly J., Buss E.C., Fischer T., Ottmann O.G., Emmerich B., et al. Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis. Cancer. 2007; 109(8): 1543–9.
12. Quintás-Cardama A., Kantarjian H.M., Garcia-Manero G., O’Brien S., Faderl S., Ravandi F., et al. A pilot study of imatinib, low-dose cytarabine and idarubicin for patients with chronic myeloid leukemia in myeloid blast phase. Leuk. Lymphoma. 2007; 48(2): 283–9.
13. Kantarjian H.M., O’Brien S., Keating M., Beran M., Estey E., Giralt S., et al. Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia. Leukemia. 1997; 11(10): 1617–20.
14. Kantarjian H.M., O’Brien S., Keating M., Beran M., Estey E., Giralt S., et al. Results of decitabine (5-aza-2’deoxycytidine) therapy in 130 patients with chronicmyelogenous leukemia. Cancer. 2003; 98(3): 522–8.
15. Oki Y., Kantarjian H.M., Gharibyan V., Jones D., O’Brien S., Verstovsek S., et al. Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia. Cancer. 2007; 109(5): 899–906.
16. Janssen J., Denkers F., Valk P., Cornelissen J., Schuurhuis G., Ossenkoppele G. Methylation patterns in CD34 positive chronic myeloid leukemia blast crisis cells. Haematologica. 2010; 95(6): 1036–7. doi: 10.3324/haematol.2009.015693.
17. Jelinek J., Gharibyan V., Estecio M., Kondo K., He R., Chung W., et al. Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia. PLoS One. 2011; 6(7): e22110. doi: 10.1371/journal.pone.0022110.
18. Uehara E., Takeuchi S., Yang Y., Fukumoto T., Matsuhashi Y., Tamura T., et al. Aberrant methylation in promoter-associated CpG islands of multiple genes in chronic myelogenous leukemia blast crisis. Oncol. Lett. 2012; 3(1): 190–2.
19. Ghez D., Micol J., Pasquier F., Auger N., Saada V., Spentchian M., et al. Clinical efficacy of second generation tyrosine kinase inhibitor and 5-azacytidine combination in chronic myelogenous leukaemia in myeloid blast crisis. Eur. J. Cancer. 2013; 49(17): 3666–70. doi: 10.1016/j.ejca.2013.07.147.
20. Li L., Wang L., Li L., Wang Z., Ho Y., McDonald T., Holyoake T., et al. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell. 2012; 21(2): 266–81. doi: 10.1016/j.ccr.2011.12.020.
21. Zhang B., Strauss A., Chu S., Li M., Ho Y., Shiang K., et al. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell. 2010; 17(5): 427–42. doi: 10.1016/j.ccr.2010.03.011.
Review
For citations:
Vlasova Yu.Yu., Morozova E.V., Smirnova A.G., Gindina T.L., Afanasiev B.V. Clinical efficacy of the combination of second generation tyrosine kinase inhibitors and 5-azacitidine in the treatment of chronic myeloid leukemia patient in myeloid blast crisis. Russian journal of hematology and transfusiology. 2016;61(4):215-217. (In Russ.) https://doi.org/10.18821/0234-5730/2016-61-4-215-217
Views:
566
Email this article 
