Influence of the shock-wave pulses of microsecond-range on tumor cells
A. I. Vorobiev,
L. A. Gorgidze,
V. N. Zakharov,
V. G. Chechetkin,
O. S. Kremenetskaya,
A. A. Shevelev,
N. E. Shklovskiy-Kordi https://doi.org/10.18821/0234-5730-2016-61-2-81-87
Abstract
The possibility of destruction or structural changes of tumor cells exposed to short (microsecond range) shock-wave pulses was investigated. It was shown that changes in the structural organization of the nuclear chromatin were observed under the influence of shock-wave pulses of microsecond range on large tumor cells. The effect of tumor cells damage was achieved, normal cells remained to be intact.
Supporting agencies: The study was supported by Grant of the President of Russian Federation (НШ 96-15-98100) and RFBR 13-07-00967, 13-07-00847, 14-07-00904, 16-29-12998, 16-07-01140, 16-07-01047А.
About the Authors
A. I. Vorobiev
Center for Theoretical Problems of Physico-Chemical Pharmacology;
National Research Center for Hematology
Russian Federation
Russian Federation
Researcher ID: L-2684-2013
Moscow, 119991;
Moscow, 125167
L. A. Gorgidze
Center for Theoretical Problems of Physico-Chemical Pharmacology
Russian Federation
Russian Federation
Researcher ID: P-8181-2014
Moscow, 119991
V. N. Zakharov
Moscow Radiotechnical Institute of Russian Academy of Sciences
Russian Federation
Moscow, 117519
Russian Federation
Moscow, 117519
V. G. Chechetkin
Keldysh Institute of Applied Mathematics of Russian Academy of Sciences
Russian Federation
Moscow, 125047
Russian Federation
Moscow, 125047
O. S. Kremenetskaya
Center for Theoretical Problems of Physico-Chemical Pharmacology
Russian Federation
Russian Federation
Researcher ID: N-6388-2014
Moscow, 119991
A. A. Shevelev
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
N. E. Shklovskiy-Kordi
National Research Center for Hematology
Russian Federation
Russian Federation
Shklovskiy-Kordi Nikita E., BD, PhD, senior researcher Hematological Research Center
ResearcherID is: F-7980-2016
125167, Moscow
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Review
For citations:
Vorobiev A.I., Gorgidze L.A., Zakharov V.N., Chechetkin V.G., Kremenetskaya O.S., Shevelev A.A., Shklovskiy-Kordi N.E. Influence of the shock-wave pulses of microsecond-range on tumor cells. Russian journal of hematology and transfusiology. 2016;61(2):81-87. (In Russ.) https://doi.org/10.18821/0234-5730-2016-61-2-81-87
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