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Гематология и трансфузиология

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Полиморфизм генов MICA и MICB в комплексе МНС

https://doi.org/10.18821/0234-5730-2016-61-2-100-104

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Аннотация

Представлены данные литературы, отражающие структуру и функцию открытых в конце XX века генов локуса MIC, характеризующихся высоким полиморфизмом. Показано, что они играют важную роль в процессах межклеточного взаимодействия, участвуют в реализации реакций врожденного и адаптивного иммунитета в качестве лигандов для рецепторов NKG2D, экспрессированных на различных субпопуляциях Т-лимфоцитов. Изложены известные на сегодняшний день сведения об ассоциативной связи генов локуса MIC с заболеваниями, их влияние на исход трансплантаций. Один из разделов статьи посвящен анализу популяционных особенностей распределения аллелей MICA и MICB. Использованы 62 источника литературы, из них 3 отечественных, 47 зарубежных, представленных в следующих информационных системах: PubMed, Google Scholar, Scopus, Springer, The Cochrane Library, Wiley Online Library, РИНЦ.

Об авторах

Г. А. Зайцева
ФГБУН «Кировский научно-исследовательский институт гематологии и переливания крови» ФМБА России
Россия

Зайцева Галина Алексеевна, доктор мед. наук, профессор, руководитель научного направления

610027, г. Киров



А. Н. Киселева
ФГБУН «Кировский научно-исследовательский институт гематологии и переливания крови» ФМБА России
Россия
610027, г. Киров


И. В. Парамонов
ФГБУН «Кировский научно-исследовательский институт гематологии и переливания крови» ФМБА России
Россия
610027, г. Киров


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Для цитирования:


Зайцева Г.А., Киселева А.Н., Парамонов И.В. Полиморфизм генов MICA и MICB в комплексе МНС. Гематология и трансфузиология. 2016;61(2):100-104. https://doi.org/10.18821/0234-5730-2016-61-2-100-104

For citation:


Zaitseva G.A., Kiseleva A.N., Paramonov I.V. Major histocompatibility complex class I chain-related gene A (MICA) and B (MICB) polymorphism. Russian journal of hematology and transfusiology. 2016;61(2):100-104. (In Russ.) https://doi.org/10.18821/0234-5730-2016-61-2-100-104

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