Major histocompatibility complex class I chain-related gene A (MICA) and B (MICB) polymorphism
https://doi.org/10.18821/0234-5730-2016-61-2-100-104
Abstract
There are presented data of the literature about the structure and function of the opened at the end of XX century the genes of the MIC locus, characterized by high polymorphism. They play an important role in cell-cell interactions involved in the implementation of responses of the innate and adaptive immunity as ligands for the NKG2D receptors expressed on different subpopulations of T-lymphocytes. There is relationship between MIC locus genes with diseases and their impact on the outcome of transplants. Population characteristics and distribution of MICA and MICB alleles are described.
About the Authors
G. A. Zaitseva
Kirov Research Institute of Hematology and Blood Transfusion
Russian Federation
Russian Federation
Zaitseva Galina A., MD, PhD, professor, head of the scientifc direction
Kirov, 610027
A. N. Kiseleva
Kirov Research Institute of Hematology and Blood Transfusion
Russian Federation
Kirov, 610027
Russian Federation
Kirov, 610027
I. V. Paramonov
Kirov Research Institute of Hematology and Blood Transfusion
Russian Federation
Kirov, 610027
Russian Federation
Kirov, 610027
References
1. Haitov R.M. Genomic HLA: new opportunities for human molecular genetics in the diagnosis and therapy. Molecular Medicine. Russian journal (Molekulyarnaya meditsina). 2003; 1: 17–31. (in Russian)
2. Frigoul A., Lefranc M.P. MICA Standardized IMGT alleles nomenclature, polymorphisms and diseases. Recent Res. Devel. Human Genet. 2005; 3: 95–145. http://www.ld.ru/w/biometra/mica.pdf
3. Gupta G.S. Animal lectins: form, function and clinical application. New York: Springer; 2012.
4. Bahram S. MIC genes: from genetics to biology. Adv. Immunol. 2001; 76: 1–60.
5. Stastny P. Introduction: MICA/MICB in innate immunity, adaptive immunity, autoimmunity, cancer and in the immune response to transplants. Human Immunol. 2006; 67(3): 141–4.
6. Collins R.W. Human MHC class I chain related (MIC) genes: their biological function and relevance to disease and transplantation. Eur. J. Immunogenet. 2004; 31(3): 105–14.
7. Yarilin A.A. Immunology: textbook. Moscow: GEOTAR-Media; 2010. (in Russian)
8. Kirijas M, Spiroski M. MICA Polymorphism, Association with Diseases and Role of Anti-MICA Antibodies in Organ and Cell Transplantation. Macedonian J. Med. Sci. 2013; 6(3): 285–95.
9. Gonzalez S., Groh V., Spies T. Immunobiology of human NKG2D and its ligands. Curr. Top. Microbiol. Immunol. 2006; 298: 121–38.
10. Janeway C.A., Travers P., Walport M., Shlomckik M. Immunobiology: the Immune System in Health and Disease. 5th ed. New York: Garland Science; 2001.
11. Choy M.K., Phipps M.E. MICA polymorphism: biology and importance in immunity and disease. Trends Mol. Med. 2010; 16(3): 97–106. doi: 10.1016/j.molmed.2010.01.002.
12. Murphy K.M. Janeway’s Immunobiology. 8th ed. New York: Garland Science; 2011.
13. Duchmann R., Blumberg R.S., Neurath M.F., Scholmerich J., Warren Strober, Zeitz M., et al., eds. Mechanisms of Intestinal Inflamation: Implications for Therapeutic Inretvention in IBD. Part 1. Kluwer Academic Publishers; 2004.
14. Hillyer C.D., Elberstein L., Ness P.M., Anderson K.C., Roback J.D. Blood banking and transfusion medicine: basic principles & practice. 2nd ed. Philadelphia: Elsevier Health Sciences; 2007.
15. Cerwenka A, Lanier L.L. NK/G2D ligands: class I-like molecules exploited by viruses and cancer. Tissue Antigens. 2003; 61(5): 335–43.
16. Ahmad T., Marshall S.E., Jewell D. Genetics of inflammatory bowel disease: the role of HLA complex. Wld J. Gastroenterol. 2006; 12(23): 3628–35.
17. Mameli A., Cauli A., Taccari E., Scarpa R., Punzi L., Lapadula G., et al. Association of MICA alleles with psoriatic arthritis and its clinical forms. A multicenter Italian study. Clin. Exp. Rheumatol. 2008; 26(4): 649–52.
18. Romphruk A.V., Romphruk A., Choonhakarn C., Puapairoj C., Inoko H., Leelayuwat C. Major histocompatibility complex class I chain-related gene A in Thai psoriasis patients: MICA association as a part of human leukocyte antigen-B-Cw haplotypes. Tissue Antigens. 2004; 63(6): 547–54.
19. Pollock R., Chandran V., Barrett J., Eder L., Pellett F., Yao C., et al. Differential major histocompatibility complex class I chain-related A allele associations with skin and joint manifestations of psoriatic disease. Tissue Antigens. 2011; 77(6): 554–61. doi: 10.1111/j.1399-0039.2011.01670.x.
20. Zhou X., Wang J., Zou H., Ward M.M., Weisman M.H., Espitia M.G., et al. MICA, a gene contribution strong susceptibility to ankylosing spondylitis. Ann. Rheum. Dis. 2014; 73(8): 1552–57. doi: 10/1136/annrheumdis-2013-203352.
21. Goto K., Ota M., Maksymowych W.P., Mizuki N., Yabuki K., Katsuyama Y., et al. Association between MICA gene A4 allele and acute anterior uveitis in white patients with and without HLA-B27. Am. J. Ophthalmol. 1998; 126(3): 436–41.
22. Gambelunghe G., Falorni A., Ghaderi M. Microsatellite polymorphism of the MHC class I chain – related (MIC-A and MIC-B) genes marks the risk for autoimmune Addison’s disease. J. Clinic. Endocrinol. Metabol. 1999; 84(10): 3701–07.
23. Cohen R., Metzger S., Nahir M., Chajek-Shaul T. Association of the MIC-A gene and HLA-B51 with Behcet’s disease in Arabs and non Ashkenazi Jews in Israil. Ann. Rheum. Dis. 2002; 61(2): 157–60.
24. Gambelunghe G., Ghaderi M., Cosentino A., Falorni Ad., Brunetti P., Falorni A., Sanjeevi C.B. Association of MHC class I chain-related A (MIC-A) gene polymorphism with type I diabetes. Diabetologia. 2000; 43(Issue 4): 507–14.
25. Trofmov D., Sergeev I., Grudakova E., Alexeev L. The MICA alleles frequencies in healthy Russians and in type I diabetic patients. Eur. J. Immunogenet. 2002; 29(2): 147.
26. Nikitina-Zake L., Gupta M., Gambelunghe G., Shtauvere G., Lernmark A. Frequencies of MICA alleles signifcantly differs between Latvian, Italian and Swedish populations and are associated with type I diabetes mellitus. Tissue Antigens. 2002; 59(2): 55.
27. Raha O., Sarkar B.N., Veerraju P., Sudhakar G., Raychaudhuri P., Mukhopadhyay S., Rao V.R. Role of MICA Repeat Polymorphism in the Manifestation of Type I Diabetes Mellitus in Bengal Indian Patients. Genetika. 2013; 45(2): 611–9. doi: 10.2298/GENSR1302611R.
28. Gambelunghe G., Gerli R., Bocci E.B., Sindaco P.D., Ghaderi M., Sanjeevi C.B., et al. Contribution of MHC class I chain-related A (MICA) gene polymorphism to genetic susceptibility for systemic lupus erythematosus. Rheumatology. 2005; 44(3): 287–92. doi:10.1093/rheumatology/keh459.
29. Dambrauskas Z., Svensson., Joshi M., Hyltander A., Neredi P., Iresjo B. Expression of major histocompatibility complex class I-related chain AB (MICA/B) in pancreatic carcinoma. Inter. J. Oncol. 2014; 44(1): 99–104. doi: 10.3892/ijo.2013.2156.
30. Zwirner N.W., Fuertes M.B., Girart M.V., Domaica C.I., Rossi L.E. Immunobiology of the human MHC class I chain-related gene A (MICA): from transplantation immunology to tumor immune escape. Immunologia. 2006; 25(1): 25–38.
31. Reinders J., Rozemuller E., Slootweg P., Tilanus M. The MICA-A9 allele is signifcantly decreased in Dutch HNSCC patients diagnosed with mouth cavity tumor. Tissue Antigens. 2002; 59(2): 106.
32. Kumar V., Lo P.H., Sawai H., Kato N., Takahashi A., Deng Z., et al. Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV – induced hepatocellular carcinoma. PloS One. 2012; 7(9): e44743. doi: 10.1371/journal.pone.0044743.
33. Luo Q.Z., Lin L., Gong Z., Mei B., Xu Y.J., Huo Z., et al. Positive association of major histocompatibility complex class I chain-related gene A polymorphism with leukemia susceptibility in the people of Han nationality of Southern China. Tissue Antigens. 2011; 78(3): 178–84.
34. Hue S., Berrih-Aknin S., Monteiro R., Caillat-Zueman S. MICA – NKG2D interactions with in normal and pathologic thymus. Tissue Antigens. 2002; 59(2): 40.
35. Kanto T., Hayashi N. Innate immunity in hepatitis C virus infection: Interplay among dendritic cells, natural killer cells and natural killer T-cells. Hepatol. Res. 2007; 37(Suppl.3): 319–26.
36. Harapan H., Fajar J., Khalilullah S., Winardi W., Jamil K. Genetic Polymorphisms of HLA and HLA-Related Proteins Implications on Dengue Virus Infection. J. Mosquito Res. 2013; 3(1): 1–10.
37. Zdrenghea M.T., Telcian A.G., Laza-Stanca V., Bellettato C.M. RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells. Eur. Respir. J. 2012; 39(3): 712–20. doi: 10.1183/09031936.00099811.
38. Lazaro F.P., Werneck F.I., Mackert C., Cobat A. et al. A Major Gene Controls Leprosy Susceptibility in a Hyperendemic Isolated Population from North of Brazil. JID. 2010; 201: 1598–605.
39. Fielding C.A., Aicheler R., Stanton R.J., Wang E.C.Y., Han S., Seirfan S., et al. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLOS Pathogens. 2014; 10(5): 1–17.
40. Danilova A.B., Fakhrutdinova O.L., Baldueva I.A., Moiseenko V.M. Immunochemical assay of MICA production by tumor cells in vitro and in vivo as a component of antitumor vaccine development. Problems in Oncology. Russian journal (Voprosy onkologii). 2010; 56(5): 576–82. (in Russian)
41. Groh V., Wu J., Yee C., Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nat. Immunol. 2002; 419(6908): 734–8.
42. Boukouaci W., Busson M., Peffault de Latour R., Rocha V., Suberbielle C., Bengoufa D., et al. MICA-129 genotype, soluble MICA, and anti-MICA antibodies as biomarkers of chronic graft-versushost disease. Blood. 2009; 114(25): 5216–24.
43. Abakushina E.V., Kuzmina E.G. Stress-induced molecules MICA/B and their role in cancer development. Molecular Medicine. Russian journal (Molekulyarnaya meditsina). 2012; 4: 16–20. (in Russian)
44. Mincheva-Nilsson L., Nagaeva O., Chen T., Stendahl U., Antsiferova J., Mogren I., et al. Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival. J. Immunol. 2006; 176(6): 3585–92. doi:10.4049/jimmunol.176.6.3289.
45. Tait B.D., Susal C., Gebel H.M., Nickerson P.W., Zachary A.A., Claas F.N., et al. Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation. 2013; 95(1): 19–47.
46. Narayan S., Tsai E.W., Zhang O., Wallace W.D., Reed E.F., Ettenger R.B. Acute rejection associated with donor-specifc anti-MICA antibody in highly sensitized pediatric renal transplant recipient. Pediatric Transpl. 2011; 15(1): 1–7.
47. Terasaki P.I., Ozawa M., Castro R. Four year follow-up of a prospective trial of HLA and MICA antibodies of Kidney graft survival. Am. J. Transpl. 2007; 7(2): 408–15.
48. Parmar S., DeLima M., Zou Y., Patah P.A., Liu P., Cano P., et al. Donor – recipient mismatches in MHC class I chain – related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versushost disease. Blood. 2009; 114(14): 2884–7.
49. Zou Y., Zhang M., Lavingia B. Allontibodies against MICA alleles in sera from kidney transplant patients react with the alfa-2 domain of MICA antigens. Tissue Antigens. 2002; 59(Suppl.2): 42.
50. Zou Y., Statny P., Susal C. Antibodies against MICA antigens and kidneytransplant rejection. N. Engl. J. Med. 2007; 357(13): 1293–1300.
51. Zhang M., Lu F., Qu L., He J., Yuan X.N., Gu Y. Serum major-histocompatibility–complex class I–related chain A antibody detection for the evaluation of graft dysfunction in renal allograft recipients. Chin. Med. J. 2011; 124(14): 2127–31.
52. Ozawa M., Rebellato L.M., Terasaki P., Tong A., Briley K.P., Catrou P., et al. Longitudinal testing of 266 renal allograft patients for HLA and MICA antibodies: Greenville experience. Clin. Transpl. 2006: 265–90.
53. Lemy A., Andrien M., Lionet A., Laballete M., Noel C., Hiesse C. Posttransplant major histocompatibility complex Class I chain-related gene A antibodies and long-term graft outcomes in a Multicenter Cohort of 779 Kidney Transplant. Transplantation. 2012; 93(12): 1258-64.
54. Suarez-Alvarez B., Lopez-Vazguez A., Gonzalez M.Z., Fdez-Morera J.L., Diaz-Molina B., Blanco-Gelaz M.A., et al. The relationship of antiMICA antibodies and MICA expression with heart allograft rejection. Am. J. Transplant. 2007; 7(7): 1842–8.
55. Kauke T., Kaszmarek L., Dick A., Schomoeckel M., Deutsch M.A., Beiras-Fernandez A., et al. Anti-MICA antibodies are related to adverse outcome in heart transplant recipients. J. Transplant. 2009; 28(4): 305–11.
56. Smith J.D., Brunner V.M., Jigjidsuren S., Hamour I.M. Lack of effect of MICA antibodies on graft survival following heart transplantation. Am. J. Transplant. 2009; 9(8): 1912–9. doi: 10.1111/j.1600-6143.2009.02722.x.
57. Sohn Y.H., Cha C.H., Oh H.B., Kim M.H., Choi S.E., Kwon O.J. MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1* in Koreans. Tissue Antigens. 2010; 75(1): 48–55.
58. Vavilov M.N., Suslova T.A., Burmistrova A.L., Darke C. HLA and MICB alleles in ancestral haplotypes in Russian and Bashkir populations of the Chelyabinsk Region of Russian South Urals. Tissue Antigens. 2012; 79(6): 531.
59. Suslova T.A., Burmistrova A.L., Chernova M.S., Khromova E.B., Lupar E., et al. HLA-gene and haplotype frequencies in Bashkirs, Russian and Tatars, living in the Chelyabinsk regions (Russian South Urals). Inter. J. Immunogenet. 2012; 39(5): 394–408. doi: 10.1111/j.1744-313X.2012.01117.x.
60. Zou Y., Stastny P. Screening for antibodies against MICA by luminex flow cytometry. Methods Mol. Biol. 2012; 882: 279–88. doi: 10.1007/978-1-61779-842-9_16.
61. Jiang X., Huang J.F., Huo Z., Zhang Q., Jiang Y., Wu X., et al. Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients. BMC Immunol. 2012; 13: 62. doi: 10.1186/1471-2172-13-62. http://www.biomedcentral.com/1471-2172/13/62
62. Zou Y., Mirbaha F., Lazaro A., Zhanq I., Lavingia B., Stastny P. MICA is a target for complement-dependent cytotoxicity with mouse monoclonal antibodies and human alloantibodies. Hum. Immunol. 2002; 63(1): 30–9.
Review
For citations:
Zaitseva G.A., Kiseleva A.N., Paramonov I.V. Major histocompatibility complex class I chain-related gene A (MICA) and B (MICB) polymorphism. Russian journal of hematology and transfusiology. 2016;61(2):100-104. (In Russ.) https://doi.org/10.18821/0234-5730-2016-61-2-100-104
Views:
764
Email this article 
