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The experience with Brentuximab vedotin in the treatment of lymphomatoid papulosis in a pediatric patient

https://doi.org/10.35754/0234-5730-2024-69-1-121-131

Abstract

Introduction. Lymphomatoid papulosis is a CD30-positive lymphoproliferative disease with primary skin lesions. One of the therapeutic options is the use of anti-CD30 monoclonal antibody brentuximab vedotin.

Aim — to present the clinical observation of the effective treatment of lymphomatoid papulosis in a 6–year-old patient using brentuximab vedotin.

Main findings. In patient K., 6 years old, after suffering from acute respiratory viral infection, the appearance of rashes was noted, located mainly on the skin of the extremities, represented by single infl ammatory papules of round shape, up to 6–8 mm in diameter, dense consistency upon palpation, with a smooth surface and a pinpoint area of white necrosis in the center of individual elements. A biopsy of one of the elements was performed. According to histological examination, a diagnosis was established: lymphomatoid papulosis, type A. Due to the ineffectiveness of therapy using topical glucocorticosteroids, oral administration of prednisolone, the patient was treated with brentuximab vedotin. A partial complete response was achieved.

 
 
 

About the Authors

A. S. Volkova
N.N. Blokhin National Medical Research Centre of Oncology
Russian Federation

Anastasiya S. Volkova, Pediatric Oncologist of the Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) № 1 of the Research Institute of Pediatric Oncology and Hematology

115478, Moscow



T. T. Valiev
N.N. Blokhin National Medical Research Centre of Oncology; Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Timur T. Valiev, Dr. Sci. (Med.), Head of the Department of Pediatric Oncology and Hematology (Chemotherapy of Hemoblastosis) № 1 of the Research Institute of Pediatric Oncology and Hematology

115478, Moscow

119991, Moscow



A. M. Kovrigina
National Medical Research Center for Hematology
Russian Federation

Alla M. Kovrigina, Dr. Sci. (Biol.), Head of the Pathology Department

125167, Moscow

   


T. S. Belysheva
N.N. Blokhin National Medical Research Centre of Oncology
Russian Federation

Tatyana S. Belysheva, Dr. Sci. (Med.), Leading Researcher of the Scientific Advisory Division

115478, Moscow



S. R. Varfolomeeva
N.N. Blokhin National Medical Research Centre of Oncology
Russian Federation

Svetlana R. Varfolomeeva, Dr. Sci. (Med.), Professor, Director of the Research Institute of Pediatric Oncology and Hematology

115478, Moscow



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For citations:


Volkova A.S., Valiev T.T., Kovrigina A.M., Belysheva T.S., Varfolomeeva S.R. The experience with Brentuximab vedotin in the treatment of lymphomatoid papulosis in a pediatric patient. Russian journal of hematology and transfusiology. 2024;69(1):121-131. (In Russ.) https://doi.org/10.35754/0234-5730-2024-69-1-121-131

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