Radiosynovectomy for hemophilic arthropathies. Analysis of opportunities and prospects
https://doi.org/10.35754/0234-5730-2024-69-2-226-235
Abstract
Introduction. A characteristic symptom of hemophilia is joint hemorrhage (hemarthroses).
Aim: to evaluate the possibilities of radiosynovectomy in hemophilic arthropathies.
Main findings. Radiosynovectomy (RSE) or radiosynoviorthesis (RSO) is a technique that achieves a long-lasting effect in chronic synovitis and hemophilic arthropathy. It consists of intra-articular injection of radiopharmaceuticals (RFLP) in the form of colloidal solutions, macroaggregates or microspheres containing radioactive isotopes, which are rapidly phagocytized by the covering cells of the synovial membrane. After such capture, the synovial sheath is subjected to intensive “internal” irradiation, which results in superficial fibrosis of synovial tissue and persistent suppression of joint inflammation.
Keywords
hemophilia,
hemophilic arthropathy,
radiosynovectomy,
radiopharmaceuticals,
Re-188,
Re-186,
P-32,
Y-90
About the Authors
V. V. Krylov
Tsyb Medical Radiological Research Centre — branch of the National Medical Research Radiological Centrе
Russian Federation
Russian Federation
Valery V. Krylov, Dr. Sci. (Med.), radiologist, head of the department of radiosurgical treatment with open radionuclides
249036, Obninsk
A. A. Zheleznov
Tsyb Medical Radiological Research Centre — branch of the National Medical Research Radiological Centrе
Russian Federation
Russian Federation
Alexander A. Zheleznov, Resident of the department of radiosurgical treatment with open radionuclides
249036, Obninsk
V. Yu. Zorenko
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Vladimir Yu. Zorenko, Dr. Sci. (Med.), traumatologist-orthopedist, Head of the Department of traumatology and reconstructive orthopedics for patients with hemophilia
125167, Moscow
A. Yu. Kim
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Alexander Yu. Kim, traumatologist-orthopedist, postgraduate student of traumatology and reconstructive orthopedics for patients with hemophilia
125167, Moscow
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Review
For citations:
Krylov V.V., Zheleznov A.A., Zorenko V.Yu., Kim A.Yu. Radiosynovectomy for hemophilic arthropathies. Analysis of opportunities and prospects. Russian journal of hematology and transfusiology. 2024;69(2):226-235. (In Russ.) https://doi.org/10.35754/0234-5730-2024-69-2-226-235
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