Thrombophilia as a reason for the development of ischemic stroke at young age. Features of the clinic and diagnosis
E. A. Savchuk,
S. A. Melnichenko,
A. V. Kurtadzhieva,
E. O. Savchuk,
P. E. Maksimova,
E. Yu. Zyablitskaya https://doi.org/10.35754/0234-5730-2024-69-2-247-259
Abstract
Introduction. Thrombophilia is a common cause of neurological complications.
Aim. to present a clinical observation of the development of ischemic stroke in a patient with hereditary thrombophilia.
Main findings. A case is presented of a man, aged 30, who developed an ischemic stroke in the basin of the left medial artery. A diagnostic study revealed that the development of the ischemic stroke was facilitated by thrombophilia caused by a combination of polymorphic variants of the fibrinogen genes (G-455A(G-467A)) and methylenetetrahydrofolate reductase (C677T). Thus, hereditary thrombophilia was a risk factor for the development of ischemic stroke in the patient at a young age. Therefore, in the absence of traditional risk factors for the development of ischemic stroke, a genetic analysis for thrombophilia is necessary.
About the Authors
E. A. Savchuk
Medical Institute named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Elena A. Savchuk, Cand. Sci. (Med.), Associate Professor of the Department of Nervous Diseases and Neurosurgery
295051, Simferopol, Republic of Crimea
S. A. Melnichenko
Semashko Republican Clinical Hospital
Russian Federation
Russian Federation
Sofia A. Melnichenko, neurologist
295017, Simferopol, Republic of Crimea
A. V. Kurtadzhieva
City Clinical Hospital No. 7
Russian Federation
Russian Federation
Anastasia V. Kurtadzhieva, neurologist
295024, Simferopol, Republic of Crimea
E. O. Savchuk
Medical Institute named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Elena O. Savchuk, assistant of the Department of Nervous Diseases and Neurosurgery
295051, Simferopol, Republic of Crimea
P. E. Maksimova
Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Рolina E. Maksimova, resident doctor in the specialty “Hematology”
197022, St. Petersburg
E. Yu. Zyablitskaya
Medical Institute named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Evgenia Yu. Zyablitskaya, Dr. Sci. (Med.), Leading Researcher, Professor of Normal Anatomy Department
295051, Simferopol, Republic of Crimea
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For citations:
Savchuk E.A., Melnichenko S.A., Kurtadzhieva A.V., Savchuk E.O., Maksimova P.E., Zyablitskaya E.Yu. Thrombophilia as a reason for the development of ischemic stroke at young age. Features of the clinic and diagnosis. Russian journal of hematology and transfusiology. 2024;69(2):247-259. (In Russ.) https://doi.org/10.35754/0234-5730-2024-69-2-247-259
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