Cytotoxic immune cell-derived agents in hematologic neoplasms: Pre-transplant remission induction
https://doi.org/10.35754/0234-5730-2025-70-2-245-251
Abstract
Introduction. Traditional methods of pre-transplant conditioning provoke acute organ damage. Immunotherapeutic drugs that target various markers of blood cells are safer. This potential is possessed by drugs based on cytotoxic immune cells. Their use may concurrently address two treatment objectives — residual tumor clearance (induction of remission) and myeloablation — consequently improving graft acceptance while preventing graft-versus-host disease development.
Aim: to systematize information on the use of cell therapy in patients with hematologic malignancies and to evaluate the role of such therapy in preparing patients for hematopoietic stem cell transplantation (HSCT).
Main findings. Current conditioning regimens and their rationale were reviewed. Approaches to the use of immunotherapeutic agents based on cytotoxic immune cells for the treatment of patients with hematologic neoplasms are discussed, and the role of such therapy in preparing patients for HSCT is outlined.
Keywords
hematologic neoplasms,
T cells,
CAR T cells,
BiTE,
hematopoietic stem cell transplantation,
conditioning
Supporting agencies: the work was supported by the Russian Science Foundation (grant No. 23-44-00043)
About the Authors
D. V. Volkov
Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Dmitry V. Volkov*, Cand. Sci. (Biol.), Research associate, Biocatalysis Laboratory.
117997, Moscow
A. G. Gabibov
Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Alexander G. Gabibov - Dr. Sci. (Chem.), Academician of the Russian Academy of Sciences, Professor of the Russian Academy of Sciences, Head of Biocatalysis Laboratory.
117997, Moscow
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Review
For citations:
Volkov D.V., Gabibov A.G. Cytotoxic immune cell-derived agents in hematologic neoplasms: Pre-transplant remission induction. Russian journal of hematology and transfusiology. 2025;70(2):245-251. (In Russ.) https://doi.org/10.35754/0234-5730-2025-70-2-245-251
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