Tactics of platelet transfusion therapy in patients with depression of the hematopoiesis: review
https://doi.org/10.18821/0234-5730-2017-62-4-218-222
Abstract
Modern therapy of hematological diseases requires the intensive use of maintenance of high-quality and safe platelet concentrate (PC) transfusions. Transfusions of PCs are the main method of arresting hemorrhagic complications in thrombocytopenia. The highest need to PC transfusions is noted in patients with aplastic anemia (AA), myelodysplastic syndrome (MDS), acute leukemia and after transplantation of hematopoietic stem cells (THSC). Multiple PC transfusions may be a risk factor for the development of alloimmunization by leukocyte (HLA) and specific platelet (HPA) antigens. It is advisable to carry out such PC transfusion in alloimmunized patients on the basis of the individual selection with the use of immunological compatibility tests of donor-recipient pairs. In cases of multiple alloimmunization, the selection of a “donor-recipient” pair is difficult or impossible. Circulating alloantibodies and autoantibodies can be eliminated by plasmapheresis.
About the Authors
A. F. Rakhmani
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Rakhmani Anzhelika F., MD, hematologist, graduate student of the Department of processing of blood cells and cryopreservation
Moscow, 125167
E. A. Mikhaylova
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
I. V. Dubinkin
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
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Review
For citations:
Rakhmani A.F., Mikhaylova E.A., Dubinkin I.V. Tactics of platelet transfusion therapy in patients with depression of the hematopoiesis: review. Russian journal of hematology and transfusiology. 2017;62(4):218-222. (In Russ.) https://doi.org/10.18821/0234-5730-2017-62-4-218-222
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