Therapy of polycythemia vera with ruxolithinib
A. L. Melikyan,
I. N. Subortseva,
E. A. Gilyazitdinova,
A. M. Kovrigina,
A. B. Sudarikov,
А. O. Abdullaev https://doi.org/10.18821/0234-5730-2017-62-4-229-232
Abstract
Currently, methods of therapeutic the treatment of polycythemia vera (PV) are: prophylaxis of thrombotic complications with acetylsalicylic acid; erythrocytapheresis; cytoreductive therapy; treatment of thrombotic complications; therapy in special conditions (pregnancy, surgery). The first line of the treatment at a young age is interferon α, in the older age group is hydroxycarbamide. In 15–25% of cases, these drugs have low efficiency and poor tolerance. The transition to another line is indicated if the therapy is ineffective or patient is intolerant of the therapy. Results of clinical trials have proved the effectiveness of ruxolitinib, JAK2 inhibitor, in the management of splenomegaly and constitutional symptoms in patients with primary myelofibrosis and PV. A review of the literature and a description of the clinical case of the effective treatment of the PV patient ruxolitinib is presented.
About the Authors
A. L. Melikyan
National Research Center for Hematology
Russian Federation
Russian Federation
Melikyan Anait L., MD, PhD, Head of the Department of Standardization of Methods of Treatment
Moscow, 125167
I. N. Subortseva
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
E. A. Gilyazitdinova
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
A. M. Kovrigina
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
A. B. Sudarikov
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
А. O. Abdullaev
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
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Review
For citations:
Melikyan A.L., Subortseva I.N., Gilyazitdinova E.A., Kovrigina A.M., Sudarikov A.B., Abdullaev А.O. Therapy of polycythemia vera with ruxolithinib. Russian journal of hematology and transfusiology. 2017;62(4):229-232. (In Russ.) https://doi.org/10.18821/0234-5730-2017-62-4-229-232
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