COMBINATION THERAPY FOR MYELOFIBROSIS
https://doi.org/10.35754/0234-5730-2019-64-2-188-197
Abstract
Introduction. Ruxolitinib presents itself as a drug for the pathogenetic treatment of myelofibrosis (MF). New drugs have recently been developed for the treatment of MF. A search for optimal combinations of these drugs with ruxolitinib appears to be a logical approach to the development of MF therapy.
Aim. To summarize data on the use of ruxolitinib in combination with various drugs approved or currently being studied in terms of their applicability for MF treatment.
General findings. The review analyses data in publications retrieved from the PubMed and Elibrary.ru databases, including clinical cases, original research papers and reviews. We discuss preliminary results of clinical trials of various rational combination therapies, which have demonstrated a high efficacy for the forms of the disease untreatable with ruxolithinib monotherapy, e.g. bone marrow fibrosis and anemia. Combinations of ruxolithinib with azacytidine, panobinostat and α-interferon have shown the most promising results.
About the Authors
I. V. Gribkova
Scientific Practical Centre for Clinical Research and Assessment of Medical Technologies
Russian Federation
Russian Federation
Irina V. Gribkova, Cand. Sci. (Biol.), Leading Researcher, Scientific and Clinical Department
tel.: +7(499)144-00-30; 121096, Moscow, Minskaya str., 12, building 2.
Yu. A. Oleinik
N.N. Petrov National Medical Research Centre for Oncology
Russian Federation
Julia A. Oleynik, Hematologist
Russian Federation
Julia A. Oleynik, Hematologist
S. A. Shalaev
N.N. Petrov National Medical Research Centre for Oncology
Russian Federation
Sergey A. Shalaev, Hematologist
Russian Federation
Sergey A. Shalaev, Hematologist
M. V. Davydovskaya
Scientific Practical Centre for Clinical Research and Assessment of Medical Technologies;
Pirogov Medical University
Russian Federation
Russian Federation
Maria V. Davydovskaya, Dr. Sci. (Med.), Deputy Director for Research
Prof., Department of Neurology, Neurosurgery and Medical Genetics
tel.: +7(499)144-00-30.
K. A. Kokushkin
Scientific Practical Centre for Clinical Research and Assessment of Medical Technologies
Russian Federation
Konstantin A. Kokushkin, Director
Russian Federation
Konstantin A. Kokushkin, Director
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Review
For citations:
Gribkova I.V., Oleinik Yu.A., Shalaev S.A., Davydovskaya M.V., Kokushkin K.A. COMBINATION THERAPY FOR MYELOFIBROSIS. Russian journal of hematology and transfusiology. 2019;64(2):188-197. (In Russ.) https://doi.org/10.35754/0234-5730-2019-64-2-188-197
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