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ALGORITHMS FOR SOLVING PROBLEMS OF PRE-TRANSFUSION IMMUNOHEMATOLOGICAL TESTING

https://doi.org/10.35754/0234-5730-2019-64-2-222-233

Abstract

Introduction. Screening and identification of anti-erythrocyte alloimmune antibodies in recipients is an important and necessary step in their testing before blood transfusion.

Aim. To formulate algorithms that could facilitate the process of pre-transfusion immunohematological testing.

General findings. Such a testing allows the development of post-transfusion reactions and complications to be avoided. The presence of alloantibodies of various specificities and autoantibodies in the test blood may complicate pre-transfusion testing and require the use of additional methods (adsorption, elution, etc.). The author has proposed an effective system of algorithms for conducting immunohematological studies, which can be used to identify patients at risk of developing immune post-transfusion complications and ensure an individual selection of compatible donor blood-transfusion products.

About the Author

I. A. Pashkova
Research Institute — Regional Clinical Hospital 1 n.a. Prof. S.V. Ochapovsky, Ministry of Healthcare of Krasnodar Krai, Kuban State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation

Irina A. Pashkova, Dr. Sci. (Med.), Head of the Blood Transfusion Department 

тел.: +7(861)252-52-59, +7(906)187-21-81; 350086, Krasnodar, 1st of May str., 167



References

1. Garratty G., Arndt P.A. Positive direct antiglobulin tests and hemolytic anemia following therapy with beta-lactamase inhibitor containing drugs may be associated with nonimmunologic adsorption of protein onto red blood cells. Br J Haematology.1998; 100: 777–83.

2. Issitt P.D., Anstree D.J. Applied blood group serology. 4th ed. Montgomery: Scientific Publications; 1998. 1208 p.

3. Milkins C., Berryman J., Cantwell C., et. al. Guidelines for pre-transfusion compatibility procedures in blood transfusion laboratories. British Committee for Standards in Haematology. Transfusion Medicine. 2013; 23(1): 3–35.

4. Mineeva N.V., Bodrova N.N., Zavarzina O.A., et al. Error analysis during immunohematological studies. Vestnik sluzhby krovi. 2007; 2: 3–5 (In Russian).

5. Mineeva N.V. Improving the system for ensuring transfusions compatible with red blood cell antigens. Zdravoohranenie i medicinskaya tekhnika. 2004; 5(9): 25–7 (In Russian).

6. Mineeva N.V., Butina Е.V. Immunohematological examination of blood donors and/or its components and recipients. Metodicheskie ukazaniya MU FMBA Rossii 11.6.1-2017 (In Russian).

7. Pashkova I.A., Ryzhanova L.G., Fedorenko T.V., et al. Analysis of the specificity of alloimmune antibodies detected in recipients. Gematologiya i transfuziologiya. 2009; 54(5): 31–4 (In Russian).

8. Pashkova I., Porhanov V., Gilevich I., et al. Surgeon patients and Transfusion in a Krasnodar regional hospital. Vox Sanguinis. 2013; 105(1): 266.

9. Brecher M.E. (editor). Technical Manual AABB, 15th Edition; 2005. 407–81 p.

10. Haas F.J.L.M., van Rhenen D.J., de Vries R.R.P. Guidelines for compatibility procedures in blood transfusion laboratories. Transfusion Medicine. 2004; 14: 59–73.

11. Mineeva N.V. Blood groups. Osnovy immunologii. St. Petersburg; 2004. 188 p. (In Russian).

12. Prokop O., Geler V. Blood groups. Moscow: Medicine; 1991. 511 p. (In Russian).

13. Mineeva N.V. Antibodies to erythrocyte antigens and methods for their detection. Guidelines. St. Petersburg; 2000. 14 p. (In Russian).

14. Mineeva N.V., Bodrova H.H., Trofimova S.A. The value of the enzyme method for the detection of clinically significant anti-erythrocyte antibodies. Novoe v transfuziologii. 2001; 29: 55–8 (In Russian).

15. Klapper E., Zhang Y., Figueroa P., et. al. Toward extended phenotype matching: a new operational paradigm for the transfusion service. Transfusion. 2010; 50(3): 536–46.

16. Sapatnekar S., Figueroa P.I. How do we use molecular red blood cell antigen typing to supplement pretransfusion testing? Transfusion. 2014; 54(6): 1452–8.

17. Garratty G., Postoway N., Nance S., Brunt D. Spontaneous agglutination of red cells with a positive direct antiglobulin test in various media. Transfusion. 1984; 24: 214–7.


Review

For citations:


Pashkova I.A. ALGORITHMS FOR SOLVING PROBLEMS OF PRE-TRANSFUSION IMMUNOHEMATOLOGICAL TESTING. Russian journal of hematology and transfusiology. 2019;64(2):222-233. (In Russ.) https://doi.org/10.35754/0234-5730-2019-64-2-222-233

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ISSN 0234-5730 (Print)
ISSN 2411-3042 (Online)