Hypercoagulation syndrome: classification, pathogenesis, diagnostics, and therapy

Hypercoagulation syndrome is the expressed coagulopathy characterized by the increased readiness to thrombosis with clinical and laboratory evidence for a blood hypercoagulable state and activation of blood clotting factors, but without acute thrombosis. Hypercoagulation syndrome is associated with several pathological conditions (erythrocytosis, hyperthrombocytosis, lesions of the blood vessel wall due to trauma, inflammation, atherosclerosis, antiphospholipid syndrome, tumors, etc.). The management of hypercoagulation syndrome is specific in every case, but almost always requires the treatment of the essential disease, antiaggregation and anticoagulation therapy, often – plasmapheresis, fresh-frozen plasma transfusions, glucocorticoids. The lack both of correction of pathological states causing hypercoagulation syndrome, permanent physician care in chronic hypercoagulatijn syndrome and timely measures for its correction can lead to the development of acute thrombosis, infarction, stroke which pose the real danger for the life of the patient.

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