The experience of the repeated administration of vitamin K for the prevention of hemorrhagic syndrome in premature infants
N. S. Bozhbanbayeva, 
E. M. Satbaeva,
A. M. Seytalieva,
G. B. Altynbayeva,
I. E. Suleimenova,
G. M. Pichkhadze
E. M. Satbaeva,
A. M. Seytalieva,
G. B. Altynbayeva,
I. E. Suleimenova,
G. M. Pichkhadze https://doi.org/10.18821/0234-5730-2016-61-3-150-153
Abstract
The purpose of this study is the investigation of the effectiveness of the repeated administration of vitamin K1 to preterm infants. 88 preterm infants were administered vitamin K1 in first hours of life at a dose of 1 mg intramuscularly, then repeatedly at 7th, 14th, 21th day after birth. Infants in the control group received vitamin K1 in a dose of 1 mg once at birth. The effectiveness of repeated administration of vitamin K1 was evaluated by the results of clinical, laboratory and instrumental data on the 21th day of life. The results showed that repeated administration of vitamin K1 reduces the length of stay of children in the ICU (15 ± 5.3 days in the study group, 18 ± 6 days in the control group), decreases of activated partial thromboplastin time as compared to the control group (53 to 29; p< 0.005), increases of prothrombin index (from 59.6 ± 7.2% to 86.7 ± 5%; p< 0.005), decreases of the number of children with retinopathy (6.5 ± 3.6% in the study group and 23.8 ± 6.6%; in the control (p< 0.05).
About the Authors
N. S. Bozhbanbayeva
S.D. Asfendiyarov Kazakh National Medical University
Kazakhstan
Almaty, 050000
Kazakhstan
Almaty, 050000
E. M. Satbaeva
S.D. Asfendiyarov Kazakh National Medical University
Kazakhstan
Kazakhstan
Satbaeva Elmira, MD, PhD, Head of the Department of Pharmacology
Almaty, 050000
A. M. Seytalieva
S.D. Asfendiyarov Kazakh National Medical University
Kazakhstan
Almaty, 050000
Kazakhstan
Almaty, 050000
G. B. Altynbayeva
S.D. Asfendiyarov Kazakh National Medical University
Kazakhstan
Almaty, 050000
Kazakhstan
Almaty, 050000
I. E. Suleimenova
S.D. Asfendiyarov Kazakh National Medical University
Kazakhstan
Almaty, 050000
Kazakhstan
Almaty, 050000
G. M. Pichkhadze
S.D. Asfendiyarov Kazakh National Medical University
Kazakhstan
Almaty, 050000
Kazakhstan
Almaty, 050000
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Review
For citations:
Bozhbanbayeva N.S., Satbaeva E.M., Seytalieva A.M., Altynbayeva G.B., Suleimenova I.E., Pichkhadze G.M. The experience of the repeated administration of vitamin K for the prevention of hemorrhagic syndrome in premature infants. Russian journal of hematology and transfusiology. 2016;61(3):150-153. (In Russ.) https://doi.org/10.18821/0234-5730-2016-61-3-150-153
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