Immunoglobulin genes and stereotyped antigenic receptors in chronic lymphocytic leukemia and other lymphoproliferative diseases
https://doi.org/10.35754/0234-5730-2023-68-1-70-79
Abstract
Introduction. The mutational status of immunoglobulin heavy chain variable region genes (IGHV) is the most important prognostic factor in chronic lymphocytic leukemia (CLL). Furthermore, a significant narrowing of the IGHV gene repertoire is found in CLL and other lymphoproliferative diseases.
Aim — to review the publication data on the IGHV genes repertoire and mutational status in CLL and other lymphoproliferative diseases regarding their clinical significance.
General information. Nucleotide sequence of rearranged IGHV genes is a unique marker of a tumor clone. CLL patients with unmutated IGHV genes have an extremely unfavorable disease outcome in contrast to the patients with mutated IGHV genes. Patients with mutated IGHV genes benefit from conventional immunochemotherapy, while non-mutated IGHV patients require therapy escalation with new targeted drugs. The study of IGHV genes and stereotyped antigen receptors repertoire makes possible to identify additional groups of CLL patients with specific genetic and clinical features. Stereotype receptors are also detected in other lymphoproliferative diseases, but their clinical significance has not yet been defined. However, stereotyped receptors are found to be disease-specific.
Supporting agencies: The study had no sponsorship
About the Authors
B. V. Biderman
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Bella V. Biderman, Cand. Sci. (Biol.), Senior Researcher
Department of Molecular Hematology
125167
Moscow
A. B. Sudarikov
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Andrey B. Sudarikov, Dr. Sci. (Biol.), Head of Department
Department of Molecular Hematology
125167
Moscow
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For citations:
Biderman B.V., Sudarikov A.B. Immunoglobulin genes and stereotyped antigenic receptors in chronic lymphocytic leukemia and other lymphoproliferative diseases. Russian journal of hematology and transfusiology. 2023;68(1):70-79. (In Russ.) https://doi.org/10.35754/0234-5730-2023-68-1-70-79
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