The influence of the frequency of donor plasmapheresis on the concentration of ions and proteins in the blood of donors
https://doi.org/10.35754/0234-5730-2024-69-2-153-162
Abstract
Introduction. Plasmapheresis is a routine procedure in many blood centers. The most common complications in plasma donors are vasovagal and citrate reactions. The effects of citrate exposure, repeated with different frequency over a long period of time, have not been sufficiently studied.
Aim. to research the effect of the frequency of plasmapheresis on the concentration of ionic and protein composition in donor blood.
Materials and methods. The concentration of protein in blood serum was measured using a biochemical method. The concentration of ions was carried out using an automatic blood electrolyte analyzer. Plasma donors were divided into groups depending on gender and frequency of plasmapheresis (1–5 times a year; 6–10 times a year; 11–26 times a year). The total number of donors involved in the study was 274 (155 men and 119 women).
Results. A significant decrease in the concentration of bound calcium was revealed in the group of female donors who donated plasma 11–26 times compared to the group who donated plasma 1–5 times a year. A significant decrease in the concentration of iron ions was revealed in the group of female donors who donated plasma 11–26 times compared to the group who donated plasma 1–5 times a year. Statistically significant differences in the concentrations of total protein were revealed between all three groups of male donors, and between groups of female donors who donated plasma 1–5 times and 6–10 times a year; 1–5 times and 11–26 times a year.
Conclusion. The use of data on changes in the parameters of ion and protein metabolism in donors of different sexes and different donation frequencies reduces the risk of developing a citrate reaction due to the selective selection of plasma donors.
About the Authors
I. M. Lamzin
Ulyanovsk Regional Blood Transfusion Station
Russian Federation
Russian Federation
Ivan M. Lamzin, Cand. Sci. (Med.), Head of blood component producing department
432017, Ulyanovsk
E. V. Brylyaeva
Ulyanovsk Regional Blood Transfusion Station
Russian Federation
Russian Federation
Elena V. Brylyaeva, Cand. Sci. (Med.), Head of blood component storing department
432017, Ulyanovsk
M. E. Khapman
Ulyanovsk Regional Blood Transfusion Station
Russian Federation
Russian Federation
Marat E. Khapman, Cand. Sci. (Med.), Head
432017, Ulyanovsk
M. N. Goryachaya
Ulyanovsk Regional War Veteran’s Hospital
Russian Federation
Russian Federation
Marina N. Goryachaya, Head of clinical diagnostic laboratory
432017, Ulyanovsk
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Review
For citations:
Lamzin I.M., Brylyaeva E.V., Khapman M.E., Goryachaya M.N. The influence of the frequency of donor plasmapheresis on the concentration of ions and proteins in the blood of donors. Russian journal of hematology and transfusiology. 2024;69(2):153-162. (In Russ.) https://doi.org/10.35754/0234-5730-2024-69-2-153-162
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