PROBABILITY OF THE FINDING THE HLA-IDENTICAL RELATED DONOR FOR PATIENTS WITH HEMATOLOGICAL DISORDERS FROM FAMILIES WITH DIFFERENT NUMBERS OF CHILDREN

Transplantation of allogeneic hematopoietic stem cells is the most effective therapy for patients with hematological malignancies and other hematological disorders. The most preferable donors of allogeneic hematopoietic stem cells are the HLA-identical siblings (descendants of the same parents) because they inherit the identical with patient HLA-haplotypes. The aim of the article was to analyze the segregation of HLA-haplotypes in families of patients with hematological disorders and assessment of the probability to find HLA-identical related donor for patients from families with different number of siblings. HLA-haplotypes are inherited in accordance with Mendelian inheritance regardless of number of siblings in the family of patient with hematological disorder.The more number of siblings, the higher the probability to find HLA-identical related donor. Thus, the probability of the finding of HLA-identical related donor for patients with one sibling accounted near 27%, for patients with two siblings – 37%, for patients with three siblings – 47%. However, HLA-identical related donor can be absent for the patient in need of allogeneic hematopoietic stem cell transplantation regardless of number of his/her siblings.

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