POSSIBLE APPLICATIONS OF NONINVASIVE HEMOGLOBIN SCREENING FOR DONOR DEFERRALS
https://doi.org/10.18821/0234-5730-2017-62-1-41-46
Abstract
Introduction The application of point-of-care devices for the hemoglobin measurement with the aim of admission to donor blood donations can decrease the time of the primary analysis and its invasiveness, reduce the cost of the donation. Introduction of new methods of hemoglobin measurement requires their clinical validation.
The purpose of this study was to compare the results of hemoglobin determination in capillary and venous blood with the use of an absorption photometer HemoCue® and percutaneous reflective spectrometer Haemospect, as well as detection thresholds for donation admission for the latter approach.
Material and Methods. The study included 484 healthy volunteer donors. Hemoglobin levels were measured in the venous and capillary blood samples. The portable absorbent photometer HemoCueHb 201+ was used. For non-invasive measurement was performed by reflective spectrometer Haemospect.
Results. The mean differences of hemoglobin levels between non-invasive spectrometric and invasive photometric measurements were -2.7 g/l for venous blood and -2.1 g/l for capillary blood (goodness of fit chi-square test). The sensitivity of noninvasive hemoglobin measurement was 55.7%, specificity was 89.9%. The positive predictive value for Haemospect was 51.8%, negative – 91.2%, with the likelihood ratio (in the form of odds ratios) – 11.2.
Conclusion. Noninvasive hemoglobinometer Haemospect, comparable to the chi-square test (for goodness of fit) and predictive value with other similar portable devices, can be used for screening of donors with the establishment of restrictions to the admission donations for men with hemoglobin less than 135 g/l, for women – less than 117 g/l.
About the Authors
A. A. Kupryashov
A.N. Bakulev Scientific Center for Cardiovascular Surgery
Russian Federation
Кupryashov Aleksey A., MD, PhD, DSc., Head of the Department of Blood Transfusion of the A.N. Bakulev Scientific Center for Cardiovascular Surgery, Moscow, 121552
Russian Federation
Кupryashov Aleksey A., MD, PhD, DSc., Head of the Department of Blood Transfusion of the A.N. Bakulev Scientific Center for Cardiovascular Surgery, Moscow, 121552
T. V. Biryukova
A.N. Bakulev Scientific Center for Cardiovascular Surgery
Russian Federation
Moscow, 121552
Russian Federation
Moscow, 121552
References
1. Bockeria L.A, Samuilova D.Sh., Shvedunova V.N., Zlochevskaya E.V., Putyato N.A., Gorbenko I.Yu., et al. Hematology stress syndrome after radical correction of congenital heart disease with cardiopulmonary bypass. Ann. Surgery. Russian Journal (Annaly khirurgii). 2003; 2: 24–8. (in Russian)
2. Pasricha S.R., McQuilten Z.K., Keller A.J., Wood E.M. Hemoglobin and iron indices in nonanemic premenopausal blood donors predict future deferral from whole blood donation. Transfusion. 2011; 51(12): 2709–13.
3. Stern M., O’Meara A., Infanti L., Sigle J.P., Buser A. Prognostic value of red blood cell parameters and ferritin in predicting deferral due to low hemoglobin in whole blood donors. Ann .Hematol. 2012;91(5): 775–80.
4. Mast A.E., Schlumpf K.S., Wright D.J., Johnson B., Glynn S.A., Busch M.P., et al. Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica. 2013; 98(8): 1324–30.
5. Sumnig A., Hron G., Westphal A., Petersmann A., Kohlmann T., Greinacher A., Thiele T. The impact of noninvasive, capillary, and venous hemoglobin screening on donor deferrals and the hemoglobin content of red blood cells concentrates: a prospective study. Transfusion. 2015; 55(12): 2847–54.
6. Singh A., Dubey A., Sonker A., Chaudhary R. Evaluation of various methods of point-of-care testing of haemoglobin concentration in blood donors. Blood Transfus. 2015; 13(2): 233–9.
7. Rudolf-Oliveira R.C., Goncalves K.T., Martignago M.L., Mengatto V., Gaspar P.C., Ferreira Jdos S., et al. Comparison between two portable hemoglobinometers and a reference method to verify the reliability of screening in blood donors. Transfus. Apher. Sci. 2013; 49(3): 578–82. doi:10.1016/j.transci.2013.09.004.
8. Pagliaro P., Belardinelli A., Boko V., Salamon P., Manfroi .S, Tazzari P. L. A non-invasive strategy for haemoglobin screening of blood donors. Blood Transfus. 2014; 12(4): 458–63.
9. Hiscock R., Kumar D., Simmons S.W. Systematic review and metaanalysis of method comparison studies of Masimo pulse co-oximeters (Radical-7™ or Pronto-7™) and HemoCue® absorption spectrometers (B-Hemoglobin or 201+) with laboratory haemoglobin estimation. Anaesth. Intensive Care. 2015; 43(3): 341–50.
10. Shahshahani H.J., Meraat N., Mansouri F. Evaluation of the validity of a rapid method for measuring high and low haemoglobin levels in whole blood donors. Blood Transfus. 2013; 11(3): 385–90.
11. Patel A.J., Wesley R., Leitman S.F., Bryant B.J. Capillary versus venous haemoglobin determination in the assessment of healthy blood donors. Vox Sang. 2013; 104(4): 317–23.
12. Kim M.J., Park Q., Kim M.H., Shin J.W., Kim H.O. Comparison of the accuracy of noninvasive hemoglobin sensor (NBM-200) and portable hemoglobinometer (HemoCue) with an automated hematology analyzer (LH500) in blood donor screening. Ann. Lab. Med. 2013; 33(4): 261–7.
13. Belardinelli A., Benni M., Tazzari P.L., Pagliaro P. Noninvasive methods for haemoglobin screening in prospective blood donors. Vox Sang. 2013; 105(2): 116–20.
14. Herraiz A., Gambarte J., Lopez B., Maqueda C., Coello de Portugal C., del Valle Flores San Maria. A comparative study of three non-invasive systems for measurement of hemoglobin with HemoCue System Having Coulter LH750 as reference value. Hematology Transfus. Inter. J. 2015; 1(3): 00016. doi:10.15406/htij.2015.01.00016. http://medcraveonline.com/HTIJ/HTIJ-01-00016.pdf
15. Gayat E., Aulagnier J., Matthieu E., Boisson M., Fischler M. Non-invasive measurement of hemoglobin: assessment of two different point-ofcare technologies. PLoS One. 2012; 7(1): e30065.
16. Ardin S., Stormer M., Radojska S., Oustianskaia L., Hahn M., Gathof B.S. Comparison of three noninvasive methods for hemoglobin screening of blood donors. Transfusion. 2015; 55(2): 379–87.
17. Al-Khabori M., Al-Riyami A.Z., Al-Farsi K., Al-Huneini M., Al-Hashim A., Al-Kemyani N., Daar S. Validation of a non-invasive pulse CO-oximetry based hemoglobin estimation in normal blood donors. Transfus. Apher. Sci. 2014; 50(1): 95–8.
18. Crowley C., Montenegro-Bethancourt G., Solomons N.W., Schűmann K. Validity and correspondence of non-invasively determined hemoglobin concentrations by two trans-cutaneous digital measuring devices. Asia Pac. J. Clin. Nutr. 2012; 21(2): 191–200.
Review
For citations:
Kupryashov A.A., Biryukova T.V. POSSIBLE APPLICATIONS OF NONINVASIVE HEMOGLOBIN SCREENING FOR DONOR DEFERRALS. Russian journal of hematology and transfusiology. 2017;62(1):41-46. (In Russ.) https://doi.org/10.18821/0234-5730-2017-62-1-41-46
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