Cytokine release syndrome following chimeric antigen receptor T-cell therapy: Pathophysiology, clinical manifestations, and novel therapeutic approaches

K. V. Lepik; T. Yu. Dergacheva; M. O. Popova; A. N. Andrianov; M. Yu. Samsonov; I. S. Moiseev

Russian journal of hematology and transfusiology
Gematologiâ i transfuziologiâ

ISSN 0234-5730 (Print)
ISSN 2411-3042 (Online)

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Russian journal of hematology and transfusiology

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Lepik K.V., Dergacheva T.Yu., Popova M.O., Andrianov A.N., Samsonov M.Yu., Moiseev I.S. Cytokine release syndrome following chimeric antigen receptor T-cell therapy: Pathophysiology, clinical manifestations, and novel therapeutic approaches. Russian journal of hematology and transfusiology. 2025;70(2):229-244. (In Russ.) https://doi.org/10.35754/0234-5730-2025-70-2-229-244

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 0234-5730 (Print)
ISSN 2411-3042 (Online)

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Elena N. Parovichnikova

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About the Authors

K. V. Lepik
Pavlov First Saint Petersburg State Medical University
Russian Federation

Kirill V. Lepik - Cand. Sci. (Med.), Head of the Biotechnology Department, R. M. Gorbacheva Research Institute of Pediatric Oncology, Hematology and Transplantation.

197022, Saint Petersburg

T. Yu. Dergacheva
JSC R-Pharm
Russian Federation

Tatyana Yu. Dergacheva - Director of the Department for Medical Support of Oncology Products, Medical Directorate.

123154, Moscow

M. O. Popova
Pavlov First Saint Petersburg State Medical University
Russian Federation

Marina O. Popova - Cand. Sci. (Med.), Associate Professor, Department of Hematology, Transfusiology and Transplantology with the Course of Pediatric Oncology, Faculty of Postgraduate Education named after Professor B. V. Afanasyev.

197022, Saint Petersburg

A. N. Andrianov
JSC R-Pharm
Russian Federation

Andrey N. Andrianov - Cand. Sci. (Med.), Scientiﬁ c Advisor, Medical Documentation Division, Department of Preclinical and Clinical Development, Medical Directorate.

123154, Moscow

M. Yu. Samsonov
JSC R-Pharm
Russian Federation

Mikhail Yu. Samsonov - Cand. Sci. (Med.), Chief Medical Ofﬁcer, Medical Directorate.

123154, Moscow

I. S. Moiseev
Pavlov First Saint Petersburg State Medical University
Russian Federation

Ivan S. Moiseev - Dr. Sci. (Med.), Deputy Director for Research, R. M. Gorbacheva Research Institute of Pediatric Oncology, Hematology and Transplantation.

197022, Saint Petersburg

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Russian journal of hematology and transfusiology

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