HLA-A*/B*C*/DRB1*/DQB1-GENES AND HAPLOTYPES IN SELF-ASSESSMENT AS THE RUSSIANS DONORS OF BONE MARROW REGISTRY (NATIONAL RESEARCH CENTER FOR HEMATOLOGY)
https://doi.org/10.18821/0234-5730-2017-62-2-65-70
Abstract
Research was carried out on a representative sample of hematopoietic stem cell/bone marrow donors of the registry of the National Research Center for Hematology. According to self-assessments donors were the ethnic Russians. The distribution of HLA-allele group in HLA-A*/B*/C*/DRB1*/DQB1* loci generally was found to correspond to their distribution in other European populations, but has some specific features. These features include: the high frequency of HLA-A*25-B*18-C*12-DR*15-DQB*06 haplotype which is also specific for the other Russian populations and Poles; and the high frequency of HLA-haplotypes probably reflecting the contribution of Finno-Ugric and some Turkic components to the gene pool of Russians. The donors of registry of National Research Center for Hematology (Moscow) are the most closely related to the Russians of Chelyabinsk and Novosibirsk regions, and Poles. These donors are also more differ from Tatars and Bashkir donors, that points the need of the establishment of registries of hematopoietic stem cell/bone marrow donors in different ethnic regions of Russia. The probability of finding of a compatible donor (in case of allogeneic hematopoietic stem cells/bone marrow transplantation) for carriers of some HLA-haplotypes which are common in the Russians is higher in Russian registries than in foreign ones.
About the Authors
E. G. Khamaganova
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
Khamaganova Ekaterina G., MD, PhD, DSci., leading researcher of the laboratory of molecular hematology
E. P. Kuzminova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
R. S. Chapova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
T. V. Gaponova
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
ID: 6504211991
V. G. Savchenko
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
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Review
For citations:
Khamaganova E.G., Kuzminova E.P., Chapova R.S., Gaponova T.V., Savchenko V.G. HLA-A*/B*C*/DRB1*/DQB1-GENES AND HAPLOTYPES IN SELF-ASSESSMENT AS THE RUSSIANS DONORS OF BONE MARROW REGISTRY (NATIONAL RESEARCH CENTER FOR HEMATOLOGY). Russian journal of hematology and transfusiology. 2017;62(2):65-70. (In Russ.) https://doi.org/10.18821/0234-5730-2017-62-2-65-70
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