FACTORS ASSOCIATED WITH PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION

Cardiovascular diseases (CVDs) are the major cause of worldwide mortality. The most common CVD is essential hypertension (EH), which is registered in 40% of the adult population and 2.4–18% of children and adolescents in Russia. The study of hemostatic status in hypertensive patients indicates to the prothrombotic changes (PTC). Both EH and hemostatic disorders are known to be heredity associated. However factors related to PTC in adolescents with EH are not clearly defined.
The aim of the study was to evaluate factors potentially increasing the frequency of PTC in adolescents with EH.
Material and methods. The heritability, indices of blood pressure monitoring (BPM), hemostasis disorders and thrombophilia gene polymorphisms are studied in 97 Caucasian adolescents (aged of 14–17 years) with EH, living in the Eastern Siberia. 60 adolescents had no PTС (1st clinical group), 37 adolescents had PTС (2nd clinical group). Forty healthy age- and gender-matched adolescents are controls.
Results. We revealed an important contribution of strong family history of thrombosis, stable arterial hypertension, thrombinemia, C/T and T/T allele carriage С677Т MTHFR gene to the development of PTC in adolescents with EH.
Conclusion. Bearing in mind multifactoriality hemostatic changes in pediatric patients with cardiovascular diseases, the further researches in this are necessary.

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