SUCCESSFUL TREATMENT OF DISSEMINATED INVASIVE MYCOSIS CAUSED BY SAPROCHAETE CAPITATA IN A PATIENT WITH ACUTE LYMPHOBLASTIC LEUKEMIA
https://doi.org/10.18821/0234-5730-2017-62-3-164-168
Abstract
The case report of a rare disseminated invasive mycosis due to Saprochaete capitata in a patient with acute lymphoblastic leukemia (ALL). The main risk factors were prolonged granulocytopenia for 21 days, presence of a central venous catheter (CVC), refractory form of ALL. S. capitata was isolated from blood cultures and CVC. Invasive mycosis due to S. capitate developed in patient receiving echinocandin for 5 days and was represented by septic shock at the onset, early dissemination in the organs (liver, spleen, kidney), prolonged fever for 167 days. Clinical improvement was achieved by using the combination of voriconazole with amphotericin B and removing of CVC. Total duration of voriconazole treatment was more than 200 days, of those 101 days in combination with amphotericin B. ALL treatment was continued with concomitant voriconazole therapy after improvement of patient condition. Relapse of invasive mycosis did not occur.
About the Authors
G. A. Klyasova
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
Galina A. Klyasova, MD, PhD, prof., head of clinical-research laboratory of clinical bacteriology, mycology and antibiotic stewardship
ResearcherID: M-6329-2014
E. V. Blokhina
Central clinical hospital
Russian Federation
Moscow, 123182
Russian Federation
Moscow, 123182
V. A. Okhmat
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
ResearcherID: M-7089-2014
A. O. Malchikova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
E. N. Parovichnikova
National Research Center for Hematology
Russian Federation
Russian Federation
Moscow, 125167
ResearcherID: N-4840-2016
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For citations:
Klyasova G.A., Blokhina E.V., Okhmat V.A., Malchikova A.O., Parovichnikova E.N. SUCCESSFUL TREATMENT OF DISSEMINATED INVASIVE MYCOSIS CAUSED BY SAPROCHAETE CAPITATA IN A PATIENT WITH ACUTE LYMPHOBLASTIC LEUKEMIA. Russian journal of hematology and transfusiology. 2017;62(3):164-168. (In Russ.) https://doi.org/10.18821/0234-5730-2017-62-3-164-168
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