СOMPUTED TOMOGRAPHY IN THE DIAGNOSIS AND MONITORING OF BONE LESIONS IN MULTIPLE MYELOMA USING LOW-DOSE AND STANDARD SCANNING PROTOCOLS
https://doi.org/10.25837/HAT.2018.13..2..002
Abstract
Introduction. Computed tomography (CT) is a powerful method of medical imaging that can reveal in skeletal bones foci of destruction, soft tissue masses and pathological fractures characteristic of multiple myeloma (MM). It has a number of valuable advantages over conventional plainfilm radiography, which has traditionally been used in the diagnosis of MM. The absence of a significant difference in the radiation load between a plain radiography and a low-dose CT makes the latter the method of choice for screening for presence and extent of osteolytic lesions.
Objective. To explore the potential of low-dose computed tomography in the diagnosis of MM and to describe characteristic structural changes of bones during treatment.
Materials and methods. One hundred and eighty-eight whole-body low-dose CT scans were performed in patients with newly diagnosed MM followed by monitoring of changes in the areas of interest according to the standard protocol.
Results. Osteolytic changes were observed in 91% of patients; 49.6% of patients showed soft-tissue masses spreading beyond the affected bones. Based on the followup CT scans according to the standard scanning protocol, we established radiological criteria of a positive response to antitumor therapy. The method has been included in the Russian multiple myeloma clinical guidelines.
About the Authors
I. E. KostinaRussian Federation
Irina E. Kostina, MD, PhD. Chairman of the Department of Rentgenology and CT
M. K. Gitis
Russian Federation
L. P. Mendeleeva
Russian Federation
A. Yu. Bagramyan
Russian Federation
M. V. Solovyev
Russian Federation
E. O. Gribanova
Russian Federation
V. G. Savchenko
Russian Federation
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Review
For citations:
Kostina I.E., Gitis M.K., Mendeleeva L.P., Bagramyan A.Yu., Solovyev M.V., Gribanova E.O., Savchenko V.G. СOMPUTED TOMOGRAPHY IN THE DIAGNOSIS AND MONITORING OF BONE LESIONS IN MULTIPLE MYELOMA USING LOW-DOSE AND STANDARD SCANNING PROTOCOLS. Russian journal of hematology and transfusiology. 2018;63(2):113-123. (In Russ.) https://doi.org/10.25837/HAT.2018.13..2..002