Alterations of the bone marrow stromal microenvironment in adult patients with acute leukemia before and after treatment
V. G. Savchenko,
I. N. Shipunova,
A. E. Bigildeev,
N. I. Drize,
A. G. Turkina,
L. A. Kuzmina,
T. V. Sorokina,
E. N. Parovichnikova https://doi.org/10.18821/0234-5730-2016-61-3-122-126
Abstract
Aim of the study. To investigate two types of the bone marrow (BM) stromal precursor cells, mesenchymal stromal cells (MMSCs) and fibroblast colony-forming units (CFU-Fs), in patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML) before and after chemotherapy.
Material and methods. BM derived MMSCs and CFU-Fs withdrawn from 74 AML, ALL and CML patients before and after chemotherapy were studied.
Results. Concentration and culture characteristics of both types of precursors were shown to be altered in patients with acute leukemia and CML.
Keywords
multipotent mesenchymal stromal cells,
acute myeloid leukemia,
acute lymphoblastic leukemia,
chronic myeloid leukemia,
fibroblast colony-forming units
Supporting agencies: Russian Foundation of Basic Research, No 12-04-00457
About the Authors
V. G. Savchenko
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
I. N. Shipunova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
A. E. Bigildeev
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
N. I. Drize
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
A. G. Turkina
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
L. A. Kuzmina
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
T. V. Sorokina
National Research Center for Hematology
Russian Federation
Russian Federation
Sorokina Tamara V., MD, Doctor of the Department of HighDose Chemotherapy, Depressions of Hemopoiesis, and Bone Marrow Transplantation
Moscow, 125167
E. N. Parovichnikova
National Research Center for Hematology
Russian Federation
Moscow, 125167
Russian Federation
Moscow, 125167
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Review
For citations:
Savchenko V.G., Shipunova I.N., Bigildeev A.E., Drize N.I., Turkina A.G., Kuzmina L.A., Sorokina T.V., Parovichnikova E.N. Alterations of the bone marrow stromal microenvironment in adult patients with acute leukemia before and after treatment. Russian journal of hematology and transfusiology. 2016;61(3):122-126. (In Russ.) https://doi.org/10.18821/0234-5730-2016-61-3-122-126
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