Coexistence of multiple myeloma and chronic myeloleukosis in one patient
O. V. Rybina,
J. A. Shavel,
A. A. Petrenko,
M. V. Galaiko,
M. S. Litvinenko,
V. E. Egorkov,
A. V. Gubkin https://doi.org/10.35754/0234-5730-2020-65-4-501-513
Abstract
Intoduction. Multiple myeloma (MM) and chronic myelogenous leukaemia (CML) are two haematological malignancies developing through tumour transformation of lymphoid and myeloid progenitor cells, respectively, not sharing a common ancestry. Coexistence of the two diseases is extremely rare.
Aim. Clinical description of a patient diagnosed with CML in a few months after start of MM therapy.
Main findings. We report a clinical case of MM and CML in a 62 years-old female patient. MM was diagnosed newly and followed by 5 VD chemotherapy cycles. Treatment discontinued due to severe polyneuropathy. The patient was transferred to thalidomide maintenance therapy. CML was diagnosed 12 months after initiation of thalidomide therapy: BCR-ABL (p190), BCR-ABL (p210). Since imatinib produced short-term effect, dasatinib therapy was started. Following 16 months after the onset of dasatinib therapy, MM relapse and CML progression were diagnosed.
Keywords
multiple myeloma,
chronic myeloid leukaemia,
tyrosine kinase inhibitors,
chemotherapy,
radiation therapy
Supporting agencies: The authors are grateful to the team of the Clinical and Diagnostic Laboratory at the Central Clinical Hospital “RZD-Medicine” and staff of the National Research Center for Hematology, Ministry of Health of the Russian Federation, for help in conducting research.
About the Authors
O. V. Rybina
Central Clinical Hospital “RZD-Medicine”
Russian Federation
Russian Federation
Olga V. Rybina, Haematologist, Department of Haematology
129128, Moscow
tel.: +7 (985) 267-20-12
J. A. Shavel
Central Clinical Hospital “RZD-Medicine”
Russian Federation
Russian Federation
Jylia A. Shavel, Haematologist (higher degree), Department of Haematology
129128, Moscow
A. A. Petrenko
Botkin Moscow City Hospital
Russian Federation
Russian Federation
Andrei A. Petrenko, Haematologist
125284, Moscow
M. V. Galaiko
Central Clinical Hospital “RZD-Medicine”
Russian Federation
Russian Federation
Marya V. Galaiko, Haematologist, Department of Haematology
129128, Moscow
M. S. Litvinenko
Central Clinical Hospital “RZD-Medicine”
Russian Federation
Russian Federation
Marya S. Litvinenko, Haematologist, Department of Haematology
129128, Moscow
V. E. Egorkov
Central Clinical Hospital “RZD-Medicine”
Russian Federation
Russian Federation
Vladimir E. Egorkov, Haematologist, Department of Haematology
129128, Moscow
A. V. Gubkin
Central Clinical Hospital “RZD-Medicine”
Russian Federation
Russian Federation
Andrey V. Gubkin, Cand. Sci. (Med.), Chief Haematologist, Central Healthcare Directorate–Branch of “OAO RZhD”, Head of the Department of Haematology, Central Clinical Hospital “RZD-Medicine”
129128, Moscow
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Rybina O.V., Shavel J.A., Petrenko A.A., Galaiko M.V., Litvinenko M.S., Egorkov V.E., Gubkin A.V. Coexistence of multiple myeloma and chronic myeloleukosis in one patient. Russian journal of hematology and transfusiology. 2020;65(4):501-513. (In Russ.) https://doi.org/10.35754/0234-5730-2020-65-4-501-513
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