Comparison of quantitative and qualita- tive characteristics of the system von Willebrand factor — metalloprotease ADAMTS13 in patients with acute myocardial in farction and is chemic stroke

Introduction. The hemostasis system plays a key role in the pathogenesis of cardiovascular diseases.

Aim — to evaluate changes in quantitative and qualitative characteristics of ADAMTS13 metalloprotease and von Willebrand factor an tigen (vWF:Ag) in patients with acute myocardial in farction (AMI) and is chemic stroke (IS).

Patients and methods. The study in cluded 110 patients aged 42–95 years (median age — 64 years), of which: 65 patients with AMI aged 42–81 years (median age — 56 years) who had coronary artery thrombosis during an giography, as well as 45 patients with IS aged 40–95 years (median age — 70 years) with diagnosed cerebral artery thrombosis. All patients were tested for ADAMTS13 an tigen, ADAMTS13 activity, an tibodies to ADAMTS13 and vWF:Ag. Blood samples were obtained during an giography (arterial and venous blood) and 24 and 120 hours after an giography (venous blood).

Results. In the group of patients with AMI, an in crease in the values of the vWF:Ag in dicator was revealed, which went beyond the upper limit of the reference in terval. In patients with IS, at the beginning of the study, this in dicator was within the reference in terval and was statistically significantly lower compared to patients with AMI but in creased after 24 hours and peaked at 120 hours. When an alyzing changes in the ADAMTS13:Ag in dicator, it was found that it was statistically significantly higher at all points of the study in the group of patients with AMI, compared with the group of patients with IS, however, the values of this in dicator did not go beyond the reference in terval in patients of both groups. At the same time, the ADAMTS13:AC in dex at all points of the study was statistically significantly higher in patients with IS, compared with the group of patients with AMI, and the ADAMTS13:AB in dex. On the contrary, in the group of AMI patients, this in dicator was statistically significantly higher in all points of the study when compared with that for the group of patients with IS.

Conclusion. The study of two pathogenetic models of thrombosis demonstrated the absence of a relationship between the vWF:Ag in dex and the quantitative or qualitative characteristics of the ADAMTS13 metalloprotease. At the same time, an in crease in ADAMTS13:AB in AMI can be considered as the reason for the decrease in ADAMTS13:AC in these patients.

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