THE CASE REPORT OF CHRONIC MYELOID LEUKEMIA WITH RARE SECONDARY TRANSLOCATION T(3;7)(Q26;Q21)
https://doi.org/10.18821/0234-5730-2017-62-2-101-104
Abstract
Additional chromosome rearrangements in patients with chronic myeloid leukemia (CML) may point to the unfavorable prognosis and the progression of the disease. The aggressive course of the myeloid hematological malignancies may be associated with the change of the activity of EVI1 oncogene located in the long arm of chromosome 3 and involved in the rearrangement. The CML prognosis is very unfavorable, when structural aberrations include position of this gene. The case report shows the rare secondary translocation t(3;7) (q26;q21) in Philadelphia-positive CML patient with blast crisis. The standard cytogenetic research methods could reveal additional chromosome rearrangements associated with disease progression.
About the Authors
H. Ya. Karimov
Scientific Research Institute of Hematology and Blood Transfusion
Uzbekistan
Tashkent, 100059
Uzbekistan
Tashkent, 100059
Yu. Yu. Assesorova
Scientific Research Institute of Hematology and Blood Transfusion
Uzbekistan
Uzbekistan
Tashkent, 100059
Assesorova Yuliana Yu., MD, PhD, senior researcher of the Department of molecular medicine and cell technology
H. M. Kazakbaeva
Scientific Research Institute of Hematology and Blood Transfusion
Uzbekistan
Tashkent, 100059
Uzbekistan
Tashkent, 100059
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Review
For citations:
Karimov H.Ya., Assesorova Yu.Yu., Kazakbaeva H.M. THE CASE REPORT OF CHRONIC MYELOID LEUKEMIA WITH RARE SECONDARY TRANSLOCATION T(3;7)(Q26;Q21). Russian journal of hematology and transfusiology. 2017;62(2):101-104. (In Russ.) https://doi.org/10.18821/0234-5730-2017-62-2-101-104
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