HLA ALLELES IN BURYATS LIVING IN THE IRKUTSK REGION
https://doi.org/10.18821/0234-5730-2017-62-3-147-152
Abstract
Material and methods. Sequence based typing was used to identify human leukocyte antigen HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 alleles from 403 recruited volunteers in Irkutsk region (Buryats), Russia for unrelated hematopoietic stem cell registry.
Results. During the carried out research in the study population identified new allele, which were registered by The WHO Nomenclature Committee for Factors of the HLA System. In this population, 31 – HLA-A, 58 – HLA-B, 33 – HLA-C, 42 – HLA-DRB1, 19 – HLA-DQB1 alleles were selected. Allele frequencies more than 10% included HLA-A*24:02 (22.08%), HLA-A*02:01 (13.65%), HLA-A*01:01 (10.92%), HLA-B*40, HLA-C*03:04 (17.62%), HLA-C*06:02 (15.51%), HLA-DRB1*07:01 (13.65%), HLA-DRB1*04:01 (10.92%), HLA-DQB1*03:01 (29.9%), HLA-DQB1*02:02 (11.29%). Of the 425 five-locus HLA haplotypes were determined with software Arlequin v.3.1. The highest frequency extended five-locus haplotype – A*24:02-B*40:02-C*03: 04-DRB1*04:01- DQ*03:01 was observed with frequencies of 3,27%. Distribution of allele and haplotype analysis allowed to compare the population of Buryats with other Russian populations. Deviations from the Hardy-Weinberg law for the loci of HLA-A and HLA-DRB1 are revealed.
About the Authors
S. S. Kutyavina
Kirov Scientific-Research Institute of Hematology and Blood Transfusion
Russian Federation
Kirov, 610027
Russian Federation
Kirov, 610027
M. A. Loginova
Kirov Scientific-Research Institute of Hematology and Blood Transfusion; “Rosplasma”
Russian Federation
Russian Federation
Kirov, 610027
Kirov, 610002
Loginova Maria A., BD, PhD, head of the Research Laboratory of Applied Immunogenetics
V. V. Cheranev
Kirov Scientific-Research Institute of Hematology and Blood Transfusion
Russian Federation
Kirov, 610027
Russian Federation
Kirov, 610027
I. V. Paramonov
Kirov Scientific-Research Institute of Hematology and Blood Transfusion
Russian Federation
Kirov, 610027
Russian Federation
Kirov, 610027
M. V. Zarubin
Irkutsk Regional Blood Transfusion Station
Russian Federation
Irkutsk, 664046
Russian Federation
Irkutsk, 664046
L. N. Verevkina
Irkutsk Regional Blood Transfusion Station
Russian Federation
Irkutsk, 664046
Russian Federation
Irkutsk, 664046
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Review
For citations:
Kutyavina S.S., Loginova M.A., Cheranev V.V., Paramonov I.V., Zarubin M.V., Verevkina L.N. HLA ALLELES IN BURYATS LIVING IN THE IRKUTSK REGION. Russian journal of hematology and transfusiology. 2017;62(3):147-152. (In Russ.) https://doi.org/10.18821/0234-5730-2017-62-3-147-152
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